Transient changes in thyroid functions tests after zoledronic acid infusion
| Autor: | Paraskevi Katsichti, Helen Karga, Apostolia Zagoreou, Garyphallia Papaioannou, Maria Triantaphyllopoulou, Argyris Pardalakis, Cherry Zerva, Georgia Kassi, Irene Giagourta |
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| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
Hydrocortisone Triiodothyronine Reverse Endocrinology Diabetes and Metabolism Thyroid Gland Thyrotropin Thyroid Function Tests Zoledronic Acid Thyroid function tests Asymptomatic Endocrinology Internal medicine Humans Medicine Prospective Studies Osteoporosis Postmenopausal Triiodothyronine Bone Density Conservation Agents Diphosphonates medicine.diagnostic_test Interleukin-6 Tumor Necrosis Factor-alpha business.industry Thyroid Imidazoles Acute-phase protein Middle Aged Thyroxine C-Reactive Protein Zoledronic acid medicine.anatomical_structure Iodothyronine deiodinase Linear Models Female medicine.symptom Thyroid function business medicine.drug |
| Zdroj: | Endocrine Journal. 58:969-977 |
| ISSN: | 1348-4540 0918-8959 |
| DOI: | 10.1507/endocrj.ej11-0039 |
| Popis: | Zoledronic acid (ZA) induces an acute phase response in association with elevation of serum cytokines, which possibly alter the 3 types of iodothyronine deiodinase activity. We therefore studied the possible alteration in thyroid function tests by ZA. We investigated the acute changes in serum thyroid hormones, TSH, cortisol, white blood cells, CRP, interleukin-6 (IL-6) and tumor necrosis factor (TNF-α), before (0) and 1, 2 and 3 days after iv infusion of 5 mg ZA in 24 asymptomatic postmenopausal women with osteoporosis (ZA group) in comparison with a placebo group. In the majority of patients the ZA infusion was associated with acute phase response and fever within 24h after infusion which became attenuated on day three. Concurrently with increase in serum cortisol, CRP, IL-6 and TNF-α, on day 1 and 2, total serum T3 (TT3), free T3 (fT3), total T4 (TT4) and fT4 decreased with a nadir on day 2 in association with an increase in the fT4/fT3 ratio and reverse T3 (rT3) levels. All thyroid function changes returned to the baseline levels on day 3, with cytokines still at higher levels, although lower than those on day 2. Serum TSH remained essentially unchanged throughout the study. The changes in thyroid hormones were at least in part explained by the increased TNF-α, but not by IL-6. ZA induces short term changes in thyroid hormones, characteristic of nonthyroidal illness syndrome (NTIS), in association with an increase in TNF-α and IL-6. |
| Databáze: | OpenAIRE |
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