Dissecting diffuse large B-cell lymphomas of the 'not otherwise specified' type: the impact of molecular techniques
| Autor: | Virginia Maltoni, Sebastiano Spagnolo, Giovanna Motta, Stefano Pileri, Stefano Fiori, Valentina Tabanelli, Enrico Derenzini, Federica Melle, Angelica Calleri, Pierluigi Antoniotti, Marco Fabbri |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Microenvironment DNA Copy Number Variations Computer science Emerging technologies Review General Biochemistry Genetics and Molecular Biology World health Diffuse Large B cell Lymphoma Translational Research Biomedical 03 medical and health sciences 0302 clinical medicine Daily practice medicine Animals Humans Sequencing Copy-number variation Precision Medicine General Pharmacology Toxicology and Pharmaceutics General Immunology and Microbiology Not Otherwise Specified Sequence Analysis DNA General Medicine Articles medicine.disease Data science 030104 developmental biology 030220 oncology & carcinogenesis Lymphoma Large B-Cell Diffuse Gene expression Transcriptome Diffuse large B-cell lymphoma |
| Zdroj: | F1000Research |
| ISSN: | 2046-1402 |
| Popis: | The updated edition of the Classification of Tumours of Haematopoietic and Lymphoid Tissues, published in September 2017 by the World Health Organization (WHO), presents many important changes to the document published in 2008. Most of these novelties are linked to the exceptional development of biomolecular techniques during the last 10 years. To illustrate how much new technologies have contributed to the better classification of single entities, as well as the discovery of new ones, would go beyond the objectives of this work. For this reason, we will take diffuse large B-cell lymphoma as an example of the cognitive improvement produced by high-yield technologies (such as the gene expression profile, the study of copy number variation, and the definition of the mutational spectrum). The acquisition of this knowledge not only has a speculative value but also represents the elements for effective application in daily practice. On the one hand, it would allow the development of personalised therapy programs, and on the other it would promote the transition from the bench of the researcher's laboratory to the patient's bedside. |
| Databáze: | OpenAIRE |
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