Designing Biodegradable PHA-Based 3D Scaffolds with Antibiofilm Properties for Wound Dressings: Optimization of the Microstructure/Nanostructure
| Autor: | Jean Marc Valleton, Naila Bou Haidar, Aracelys Marcano, Stéphane Marais, A.C. Duncan |
|---|---|
| Přispěvatelé: | Polymères Biopolymères Surfaces (PBS), Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut de Chimie du CNRS (INC)-Institut Normand de Chimie Moléculaire Médicinale et Macromoléculaire (INC3M), Institut de Chimie du CNRS (INC)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Université Le Havre Normandie (ULH), Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Université de Caen Normandie (UNICAEN), Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Université Le Havre Normandie (ULH), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Materials science
Nanostructure Biomedical Engineering 02 engineering and technology [SDV.BC]Life Sciences [q-bio]/Cellular Biology 010402 general chemistry 01 natural sciences Biomaterials Polymer chemistry medicine Dispersin B [SDV.IB.BIO]Life Sciences [q-bio]/Bioengineering/Biomaterials ComputingMilieux_MISCELLANEOUS chemistry.chemical_classification Polyvinylpyrrolidone Substrate (chemistry) Polymer [CHIM.MATE]Chemical Sciences/Material chemistry 021001 nanoscience & nanotechnology Microstructure 0104 chemical sciences Solvent Membrane [CHIM.POLY]Chemical Sciences/Polymers chemistry Chemical engineering [SDV.IB]Life Sciences [q-bio]/Bioengineering 0210 nano-technology medicine.drug |
| Zdroj: | ACS Biomaterials Science and Engineering ACS Biomaterials Science and Engineering, ACS, 2017, 3 (12), pp.3654-3661. ⟨10.1021/acsbiomaterials.7b00552⟩ |
| ISSN: | 2373-9878 |
| DOI: | 10.1021/acsbiomaterials.7b00552⟩ |
| Popis: | One major factor inhibiting natural wound-healing processes is infection through bacterial biofilms, particularly in the case of chronic wounds. In this study, the micro/nanostructure of a wound dressing was optimized in order to obtain a more efficient antibiofilm protein-release profile for biofilm inhibition and/or detachment. A 3D substrate was developed with asymmetric polyhydroxyalkanoate (PHA) membranes to entrap Dispersin B (DB), the antibiofilm protein. The membranes were prepared using wet-induced phase separation (WIPS). By modulating the concentration and the molecular weight of the porogen polymer, polyvinylpyrrolidone (PVP), asymmetric membranes with controlled porosity were obtained. PVP was added at 10, 30, and 50% w/w, relative to the total polymer concentration. The physical and kinetic properties of the quaternary nonsolvent/solvent/PHA/PVP systems were studied and correlated with the membrane structures obtained. The results show that at high molecular weight (Mw = 360 kDa) and high PV... |
| Databáze: | OpenAIRE |
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