Pd/PTABS: Low Temperature Etherification of Chloroheteroarenes

Autor:	Nicolas Chrysochos, Anant R. Kapdi, Shatrughn Bhilare, Yogesh S. Sanghvi, Siva Sankar Murthy Bandaru, Jagrut Shah, Carola Schulzke
Rok vydání:	2018
Předmět:	chemistry.chemical_compound chemistry 010405 organic chemistry Organic Chemistry Synthon Molecule Phenol Estrone 010402 general chemistry 01 natural sciences Combinatorial chemistry 0104 chemical sciences Catalysis
Zdroj:	The Journal of Organic Chemistry. 83:13088-13102
ISSN:	1520-6904 0022-3263
DOI:	10.1021/acs.joc.8b01840
Popis:	A mild, general, and highly efficient catalytic etherification protocol for chloroheteroarenes was developed using the Pd/PTABS catalytic system. The protocol is selective for the etherification of chloroheteroarenes using a large variety of electron-rich and electron-deficient phenol bearing synthons which include inter alia biologically and commercially important estrone, estradiol, tyrosine, and several other molecules. The mildness of the new protocol is expected to be beneficial for the synthesis of complex drugs and drug intermediates offering late-stage modification of bioactive compounds.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c00277f0b5d43f962f3d20644eaefa3a https://doi.org/10.1021/acs.joc.8b01840 Zobrazit plný text záznamu