Expression of the TGF-β–ALK-1 Pathway in Dura and the Outer Membrane of Chronic Subdural Hematomas
| Autor: | Atsushi Saito, Ayumi Narisawa, Tatsuya Sasaki, Takahiro Morita, Seiya Sannohe, Hidekachi Kurotaki, Hiroki Takasawa, Michiharu Nishijima |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Vascular Endothelial Growth Factor A Decompressive Craniectomy transforming growth factor Pathology medicine.medical_specialty Time Factors Activin Receptors Type II Dura mater Neovascularization chemistry.chemical_compound Chronic subdural hematoma Transforming Growth Factor beta medicine Craniocerebral Trauma Humans Aged Retrospective Studies Aged 80 and over Membranes Neovascularization Pathologic Kinase business.industry Middle Aged Vascular endothelial growth factor activin kinase medicine.anatomical_structure Gene Expression Regulation chemistry chronic subdural hematoma Hematoma Subdural Chronic Disease Progression Female Original Article Surgery Dura Mater Neurology (clinical) medicine.symptom Signal transduction Tomography X-Ray Computed Bacterial outer membrane business Integrin alpha Chains Signal Transduction Transforming growth factor |
| Zdroj: | Neurologia medico-chirurgica |
| ISSN: | 1349-8029 0470-8105 |
| Popis: | Neovascularization of the outer membrane plays a critical role in the development and enlargement of chronic subdural hematomas (CSHs) and vascular endothelial growth factor (VEGF) may promote their progression. However, the precise mechanisms remain to be determined. We focused on the signaling pathway upstream of VEGF, transforming growth factor β (TGF-β), and activin receptor-like kinase 1 (ALK-1) to identify the mechanisms underlying the neovascularization of the outer membrane of CSH. Retrospective comparative study was conducted on 15 consecutive patients diagnosed as CSH with burr-hole drainage. Dura and the outer membrane were collected. We immunohistochemically examined the expression of VEGF, integrin-α, TGF-β, and ALK-1 on the outer membrane and dura of CSH and compared our findings with control samples and the signal intensity of hematomas on computed tomography (CT) scans. VEGF and integrin-α expression was markedly up-regulated in both the dura and outer membrane of CSH, the expression of TGF-β and ALK-1 in the dura was slightly increased in the dura and markedly up-regulated in the outer membrane. There was no significant correlation between their expression and CT density. Here we first report the expression of TGF-β and ALK-1 in the outer membrane and dura mater of CSH. We suggest that the TGF-β–ALK-1 pathway and VEGF affect neovascularization and the progression of CSH. |
| Databáze: | OpenAIRE |
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