Association of dyslipidaemia and oral statin use, and dry eye disease symptoms in the Blue Mountains Eye Study
| Autor: | Paul Mitchell, Ming‐Han H. Lee, George Burlutsky, Bamini Gopinath, Stephanie L Watson, Kenneth G.-J. Ooi |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Moderate to severe medicine.medical_specialty Statin medicine.drug_class Hypercholesterolemia Population Administration Oral Disease 030204 cardiovascular system & hematology Clinical correlation 03 medical and health sciences 0302 clinical medicine Surveys and Questionnaires Internal medicine Odds Ratio Humans Medicine education Aged Dyslipidemias Retrospective Studies Aged 80 and over education.field_of_study business.industry nutritional and metabolic diseases Odds ratio Middle Aged Statin treatment Lipids Confidence interval Ophthalmology Cross-Sectional Studies 030221 ophthalmology & optometry Dry Eye Syndromes Female lipids (amino acids peptides and proteins) Hydroxymethylglutaryl-CoA Reductase Inhibitors New South Wales business |
| Zdroj: | Clinical & Experimental Ophthalmology. 47:187-192 |
| ISSN: | 1442-9071 1442-6404 |
| DOI: | 10.1111/ceo.13388 |
| Popis: | Importance There is limited literature on oral statin use and its association with dry eye. Background To analyse the association between dyslipidaemia, use of oral statin drugs, and symptoms of dry eye disease (DED) among older adults. Design Population-based study. Participants Participants of the Blue Mountains Eye Study III (BMESIII), a large cohort study in suburban Sydney, aged 60 years or older (mean age = 74, range = 60-97, n = 1680) were analysed. Methods Information on DED symptoms and statin use were obtained from an interviewer-administered questionnaire. Serum lipid profiles were determined from fasting blood tests. Main outcome measures The association of various DED symptoms, as well as their number and their severity, with dyslipidaemia and oral statin intake was evaluated. Results At least one DED symptom was reported in 52% (n = 1029) of the population. Patients with hypercholesterolaemia (>5.5 mmol/L) did not report more DED symptoms than those without hypercholesterolaemia. Neither serum high-density lipoprotein nor low-density lipoprotein levels were associated with any DED symptoms. Patients taking oral statins were more likely to report one or more moderate to severe symptoms of DED (odds ratio: 2.054, 95% confidence interval: 1.281-3.295). Conclusions and relevance The association between oral statin use and presence of moderate to severe DED symptomatology is a novel finding that deserves further mechanistic and clinical correlation in order to determine its potential, or lack thereof, for the management of dry eye. |
| Databáze: | OpenAIRE |
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