7-Amino acid peptide (7P) decreased airway inflammation and hyperresponsiveness in a murine model of asthma
| Autor: | Yanying Zhao, Yun Cheng, Qibing Mei, Wanzhou Zhao, Chloe Deng, Ruihe Yu, Yahui Mi |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
Ovalbumin medicine.medical_treatment Anti-Inflammatory Agents Inflammation Proinflammatory cytokine Th2 Cells Respiratory Hypersensitivity medicine Animals Asthma Pharmacology Lung business.industry Cell Differentiation respiratory system medicine.disease respiratory tract diseases Mice Inbred C57BL Disease Models Animal medicine.anatomical_structure Cytokine Immunology Cytokines Tumor necrosis factor alpha Bronchoconstriction medicine.symptom Peptides business CD81 |
| Zdroj: | European Journal of Pharmacology. 912:174576 |
| ISSN: | 0014-2999 |
| DOI: | 10.1016/j.ejphar.2021.174576 |
| Popis: | A 7-amino acid peptide (7P), (Gly-Gln-Thr-Tyr-Thr-Ser-Gly) is one of the synthesized mimic polypeptides, which is the second envelope protein at hypervariable region 1 of chronic hepatitis C virus (HCV HVR1). It contributed to the anti-inflammatory reaction and inhibited lung Th9 responses in asthma through binding to CD81. In this study, we examined the effects of 7P on bronchoconstriction, acute inflammation of the airways, and lung Th2-type responses during allergic lung inflammation. Our results determined that 7P decreased bronchoconstriction and inhibited both acute inflammatory cytokines (TNFα, IL-1β, and IL-6) and Th2 cell cytokine responses (IL-5, IL-4, and IL-13) during allergic lung inflammation. 7P directly inhibited lung Th2 cell differentiation (7P: 5.1% vs. vehicle:12.2% and control 7P:12.2%) and suppressed airway inflammatory cytokine signal transduction to decrease Th2 cell response. Overall, 7P significantly decreased airway hyperresponsiveness (AHR), airway inflammation, and Th2 responses, which may serve as a novel therapeutic candidate during allergic lung inflammation. |
| Databáze: | OpenAIRE |
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