B subgroup detection in a small hospital transfusion service
| Autor: | E. Elardo, J. Jacobson, T. Hamilton, C. Sanchez, M. Smaris, Y. Li, N. Elbadri, D.W. Wu, T. Hilbert, V. Powell |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Transfusion service
Blood transfusion business.industry medicine.medical_treatment Transfusion Reaction Hematology General Medicine Abo gene Hospitals Small hospital Serology ABO Blood-Group System Blood Grouping and Crossmatching Pregnancy ABO blood group system Immunology medicine Immunology and Allergy Humans Blood Transfusion Female B subgroup business Genotyping |
| Zdroj: | Immunohematology. 37(2) |
| ISSN: | 0894-203X |
| Popis: | The ABO blood group system includes phenotypes, or subgroups, that differ in the amount of A and B antigens present on the red blood cells (RBCs). These subgroups also differ in the A, B, or H substances present in secretions (for individuals who have the secretor phenotype). B subgroups are very rare and are less frequently reported than A subgroups. Usually, B subgroups are discovered during serologic testing when there is a discrepancy between RBC and serum grouping results. Subgroups of B are usually identified by a reference laboratory using molecular and adsorption-elution methods. This report details a case of a young, healthy, pregnant woman with a B subgroup detected by a small transfusion service using adsorption-elution methods. Serology and genotyping of the ABO gene was performed at a reference laboratory where the serology was consistent with a B subgroup, but no changes were identified in ABO gene sequencing. It is important to correctly identify B subgroups in donors and recipients to help resolve ABO discrepancies and potentially prevent ABO incompatibility in blood transfusion, thus minimizing transfusion reactions. The ABO blood group system includes phenotypes, or subgroups, that differ in the amount of A and B antigens present on the red blood cells (RBCs). These subgroups also differ in the A, B, or H substances present in secretions (for individuals who have the secretor phenotype). B subgroups are very rare and are less frequently reported than A subgroups. Usually, B subgroups are discovered during serologic testing when there is a discrepancy between RBC and serum grouping results. Subgroups of B are usually identified by a reference laboratory using molecular and adsorption-elution methods. This report details a case of a young, healthy, pregnant woman with a B subgroup detected by a small transfusion service using adsorption-elution methods. Serology and genotyping of the ABO gene was performed at a reference laboratory where the serology was consistent with a B subgroup, but no changes were identified in ABO gene sequencing. It is important to correctly identify B subgroups in donors and recipients to help resolve ABO discrepancies and potentially prevent ABO incompatibility in blood transfusion, thus minimizing transfusion reactions. |
| Databáze: | OpenAIRE |
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