Interrelationships between mitochondrial fusion, energy metabolism and oxidative stress during development in Caenorhabditis elegans
| Autor: | Tetsuji Shoyama, Hitoshi Suda, Kayo Yasuda, Akira Akatsuka, Philip S. Hartman, Naoaki Ishii, Masaki Miyazawa, Takamasa Ishii |
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| Rok vydání: | 2011 |
| Předmět: |
Mutant
Biophysics Mitochondrion medicine.disease_cause Membrane Fusion Biochemistry GTP Phosphohydrolases Protein Carbonylation chemistry.chemical_compound Superoxides medicine Animals Caenorhabditis elegans Caenorhabditis elegans Proteins Molecular Biology chemistry.chemical_classification Reactive oxygen species biology Superoxide Wild type Cell Biology Cytochromes b biology.organism_classification Mitochondria Succinate Dehydrogenase Oxidative Stress chemistry mitochondrial fusion Energy Metabolism Oxidative stress |
| Zdroj: | Biochemical and Biophysical Research Communications. 404:751-755 |
| ISSN: | 0006-291X |
| DOI: | 10.1016/j.bbrc.2010.12.017 |
| Popis: | Mitochondria are known to be dynamic structures with the energetically and enzymatically mediated processes of fusion and fission responsible for maintaining a constant flux. Mitochondria also play a role of reactive oxygen species production as a byproduct of energy metabolism. In the current study, interrelationships between mitochondrial fusion, energy metabolism and oxidative stress on development were explored using a fzo-1 mutant defective in the fusion process and a mev-1 mutant overproducing superoxide from mitochondrial electron transport complex II of Caenorhabditis elegans. While growth and development of both single mutants was slightly delayed relative to the wild type, the fzo-1;mev-1 double mutant experienced considerable delay. Oxygen sensitivity during larval development, superoxide production and carbonyl protein accumulation of the fzo-1 mutant were similar to wild type. fzo-1 animals had significantly lower metabolism than did N2 and mev-1. These data indicate that mitochondrial fusion can profoundly affect energy metabolism and development. |
| Databáze: | OpenAIRE |
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