Effect of oral diclofenac intake on faecal calprotectin
| Autor: | Ewa Grodzinsky, Henrik Hjortswang, Stergios Kechagias, Magnus Falk, Rikard Svernlöv, Zlatica Rendek, Karl Wahlin |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Diclofenac Stool sample Administration Oral Pharmacology Gastroenterology Feces Young Adult 03 medical and health sciences 0302 clinical medicine Intestinal inflammation Internal medicine Healthy volunteers medicine Humans Lack of knowledge 030212 general & internal medicine Sweden business.industry Anti-Inflammatory Agents Non-Steroidal Middle Aged Faecal calprotectin Healthy Volunteers Discontinuation stomatognathic diseases Occult Blood Female 030211 gastroenterology & hepatology Calprotectin business Leukocyte L1 Antigen Complex medicine.drug |
| Zdroj: | Scandinavian Journal of Gastroenterology. 51:28-32 |
| ISSN: | 1502-7708 0036-5521 |
| DOI: | 10.3109/00365521.2015.1066421 |
| Popis: | NSAIDs are a known source of increased faecal calprotectin (FC) levels. Currently, there is a lack of knowledge about how long it takes for an increased FC level to return to normal after NSAID intake.The aim was to investigate how oral diclofenac intake affects FC levels and assess how long it takes for an increased FC level to return to normal after oral diclofenac intake.Thirty healthy volunteers received diclofenac 50 mg three times daily for 14 days. Participants provided a stool sample on Days 0, 2, 4, 7, 14 during intake and Days 17, 21, 28 after discontinuation. FC levels were then followed at 7-day intervals until normalization.During diclofenac intake, eight participants (27%) had FC levels exceeding the upper limit of normal (median, 76 μg/g; range, 60-958 μg/g), corresponding to 8.3% of measurements. FC was not constantly increased and became normal in most participants during diclofenac intake. FC levels were on average significantly higher during intake (M = 9.5, interquartile range (IQR) = 13.4) than on baseline (M = 7.5, IQR = 0.0), p = 0.003. After discontinuation, two participants had increased FC on Days 17 and 21, respectively. No significant differences in FC levels were found between baseline and measurements after discontinuation. Two weeks after discontinuation, all participants had normal FC levels.Short-term oral diclofenac intake is associated with increased FC levels. However, the likelihood of an increased test result is low. Our results suggest that 2 weeks of diclofenac withdrawal is sufficient to get an uninfluenced FC test result. |
| Databáze: | OpenAIRE |
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