Preclinical models of arthritis for studying immunotherapy and immune tolerance
Autor: | Pascale Wehr, Daniela Sieghart, Shaima Al Khabouri, György Nagy, Michael Bonelli, Gavin R. Meehan, Catharien M. U. Hilkens, James M. Brewer, Ranjeny Thomas, Paul Garside, Huw D. Lewis, David C. Wraith, David F. Tough |
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Rok vydání: | 2021 |
Předmět: |
rheumatoid
experimental medicine.medical_treatment Immunology Arthritis Autoimmunity Review Disease Bioinformatics medicine.disease_cause Anti-Citrullinated Protein Antibodies General Biochemistry Genetics and Molecular Biology Immune tolerance Arthritis Rheumatoid Mice 03 medical and health sciences 0302 clinical medicine Immune system Rheumatology Rheumatoid Factor Immune Tolerance therapeutics medicine Animals Immunology and Allergy Autoantibodies 030304 developmental biology 0303 health sciences business.industry Immunotherapy medicine.disease Arthritis Experimental Response to treatment Rats 3. Good health Disease Models Animal Self Tolerance arthritis Desensitization Immunologic Rheumatoid arthritis Asymptomatic Diseases Disease Progression business 030215 immunology |
Zdroj: | Annals of the Rheumatic Diseases |
ISSN: | 1468-2060 0003-4967 |
Popis: | Increasingly earlier identification of individuals at high risk of rheumatoid arthritis (RA) (eg, with autoantibodies and mild symptoms) improves the feasibility of preventing or curing disease. The use of antigen-specific immunotherapies to reinstate immunological self-tolerance represent a highly attractive strategy due to their potential to induce disease resolution, in contrast to existing approaches that require long-term treatment of underlying symptoms.Preclinical animal models have been used to understand disease mechanisms and to evaluate novel immunotherapeutic approaches. However, models are required to understand critical processes supporting disease development such as the breach of self-tolerance that triggers autoimmunity and the progression from asymptomatic autoimmunity to joint pain and bone loss. These models would also be useful in evaluating the response to treatment in the pre-RA period.This review proposes that focusing on immune processes contributing to initial disease induction rather than end-stage pathological consequences is essential to allow development and evaluation of novel immunotherapies for early intervention. We will describe and critique existing models in arthritis and the broader field of autoimmunity that may fulfil these criteria. We will also identify key gaps in our ability to study these processes in animal models, to highlight where further research should be targeted. |
Databáze: | OpenAIRE |
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