Royal jelly increases peripheral circulation by inducing vasorelaxation through nitric oxide production under healthy conditions
| Autor: | Shino Miyauchi-Wakuda, Yoshihiko Ito, Yuri Oonishi, Kazumasa Shinozuka, Yaoyue Liang, Satomi Kagota, Kana Maruyama, Shizuo Yamada |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
Tail 0301 basic medicine medicine.medical_specialty Time Factors Vasodilator Agents Aorta Thoracic In Vitro Techniques Muscarinic Agonists 030204 cardiovascular system & hematology Nitric Oxide Nitric oxide 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Mesenteric Artery Superior Oral administration Internal medicine Muscarinic acetylcholine receptor medicine Animals Rats Wistar Mesenteric arteries Pharmacology Dose-Response Relationship Drug Fatty Acids General Medicine Blood flow Acetylcholine Perfusion Vasodilation Atropine 030104 developmental biology Blood pressure medicine.anatomical_structure Endocrinology chemistry Signal Transduction medicine.drug |
| Zdroj: | Biomedicine & Pharmacotherapy. 106:1210-1219 |
| ISSN: | 0753-3322 |
| Popis: | Aims Royal jelly (RJ) has a variety of reported biological activities, including vasorelaxation and blood pressure–lowering effects. Although functional foods are positively used for health, the effects of RJ on the cardiovascular system in healthy individuals have not been well studied. Therefore, we investigated the mechanisms underlying the vasorelaxation effects of RJ in healthy control rats to evaluate whether the peripheral circulation was increased. Main Methods We used fresh RJ to examine the vasorelaxation effects and related mechanisms in Wistar rats using organ bath techniques. Furthermore, we measured changes in tail blood circulation, systolic blood pressure (sBP), and heart rate (HR) after the oral administration of RJ to control rats and nitro- l -arginine methyl ester ( l -NAME)–treated rats (0.5 mg/ml dissolved in distilled drinking water for 1 week). Concentrations of acetylcholine (ACh) in the RJ were measured using a commercial kit. Key findings RJ caused vasorelaxation of isolated rat aortas and superior mesenteric arteries, and this effect was inhibited by atropine (10−5 M, 15 min) or L-NAME (10-4 M, 20 min) and endothelium-denuded arterial ring preparations. Oral RJ increased tail blood flow and mass in control rats 1 h after treatment without affecting velocity, sBP, or HR. These effects were not observed in L-NAME–treated rats. RJ contained approximately 1000 μg/g of ACh. Significance The present study demonstrated that RJ is composed of muscarinic receptor agonist(s), likely ACh, and induces vasorelaxation through nitric oxide (NO) production from the vascular endothelium of healthy rats, leading to increased tail blood circulation. Thus, fresh RJ may improve peripheral circulation in healthy individuals. |
| Databáze: | OpenAIRE |
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