Factors associated with the level of CD4 cell counts at HIV diagnosis in a French cohort: a quantile regression approach
| Autor: | Eric Billaud, François Raffi, Léa Bruneau, Matthieu Hanf |
|---|---|
| Přispěvatelé: | Centre régional de coordination pour la lutte contre le VIH [Nantes] (COREVIH - Pays de la Loire), Unité de Soutien Méthodologique [CHU La Réunion] (USM), Centre Hospitalier Universitaire de La Réunion (CHU La Réunion), Service des maladies infectieuses [Nantes], Centre d’Investigation Clinique de Nantes (CIC Nantes), Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre hospitalier universitaire de Nantes (CHU Nantes), BRUNEAU, Léa |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male 0301 basic medicine Delayed Diagnosis quantile regression late diagnosis HIV Infections Context (language use) Dermatology medicine.disease_cause Cohort Studies 03 medical and health sciences 0302 clinical medicine Acquired immunodeficiency syndrome (AIDS) Risk Factors Antiretroviral Therapy Highly Active medicine Humans Pharmacology (medical) 030212 general & internal medicine Hepatitis B virus Coinfection business.industry Public Health Environmental and Occupational Health Middle Aged medicine.disease 030112 virology CD4 Lymphocyte Count 3. Good health Quantile regression Infectious Diseases CD4 counts [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie Immunology Cohort HIV/AIDS Female [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie France business Demography Cohort study Quantile |
| Zdroj: | International Journal of STD and AIDS International Journal of STD and AIDS, SAGE Publications, 2017, 28 (4), pp.397-403. ⟨10.1177/0956462416650980⟩ |
| ISSN: | 0956-4624 |
| Popis: | The consensus definition of late presentation for human immunodeficiency virus patient based on a CD4 threshold of 350 cells/mm3 has limitations concerning risk factors identification since there is growing biomedical justification for earlier initiation of treatment. The objective was to overcome this problem by simultaneously determining factors associated with different levels of CD4 counts at the time of diagnosis. Between January 2000 and July 2014, 1179 patients with a first human immunodeficiency virus diagnosis and entering care in a French human immunodeficiency virus reference center were enrolled. Factors associated with each 5 percentile from 5th to 95th quantile of CD4 counts at diagnosis were simultaneously studied in a multivariable quantile regression model. At each of the quantiles, the factors identified as negatively associated with CD4 count at diagnosis were older age, male sex , foreign patients, hepatitis B virus or hepatitis C virus co-infection, employment status, non-MSM transmission, heterosexual transmission, suburban and rural’s place of residence and earlier period of diagnosis. Association with CD4 count was not uniformly significant, most factors being significant for some quantiles. The only significant determinant for all quantiles was being born in a foreign country. These results are particularly helpful in the context of human immunodeficiency virus clinical care, management and prevention. |
| Databáze: | OpenAIRE |
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