Kidney growth and hypertrophy: the role of mTOR and vesicle trafficking
| Autor: | Qais Al-Awqati |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Kidney
Compensatory growth (organ) General Medicine mTORC1 Biology mTORC2 humanities Cell biology Phosphatidylinositol 3-Kinases medicine.anatomical_structure Biochemistry Commentary biology.protein medicine Animals Kidney Diseases biological phenomena cell phenomena and immunity Signal transduction Corrigendum Protein kinase B PI3K/AKT/mTOR pathway Signal Transduction RHEB |
| Zdroj: | Journal of Clinical Investigation. 125:2267-2270 |
| ISSN: | 0021-9738 |
| DOI: | 10.1172/jci81508 |
| Popis: | The kidney, like other organs, grows in constant proportion to the rest of the body. When one kidney is removed, the remaining one hypertrophies. In a comprehensive series of studies, Chen et al. show that growth during maturation is mediated by the mTORC1 signaling pathway, which is induced by EGF-like peptides, and requires PI3K, PDK, AKT, mTORC2, and activation of mTORC1 through the combined effects of TSC and RHEB as part of a multiprotein complex localized on lysosomes. However, compensatory growth is mediated by amino acids, which act on mTORC1 independently of the previous pathway, and requires a class III PI3K (VPS34) that is known to be involved in vesicle trafficking to the lysosomes. |
| Databáze: | OpenAIRE |
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