Outcome of hypovascular hepatic nodules revealing no gadoxetic acid uptake in patients with chronic liver disease
Autor: | Tsutomu Araki, Tomoaki Ichikawa, Hideki Fujii, Ali Muhi, Masanori Matsuda, Nobuyuki Enomoto, Kojiro Onohara, Fumitake Amemiya, Katsuhiro Sano, Hironobu Sou, Utaroh Motosugi |
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Rok vydání: | 2011 |
Předmět: |
Risk
medicine.medical_specialty Gadoxetic acid Contrast Media Chronic liver disease Cohort Studies Magnetics Hypertension Portal Image Processing Computer-Assisted medicine Humans Radiology Nuclear Medicine and imaging In patient Retrospective Studies business.industry Liver Diseases Hepatic nodules Hypervascularity medicine.disease Magnetic Resonance Imaging Treatment Outcome Adipose Tissue Liver Hepatocellular carcinoma Chronic Disease Disease Progression Radiology Tomography Dynamic ct Tomography X-Ray Computed Nuclear medicine business medicine.drug |
Zdroj: | Journal of Magnetic Resonance Imaging. 34:88-94 |
ISSN: | 1053-1807 |
Popis: | Purpose: To elucidate the natural history of hypovascular nodules that appear hypointense on hepatocyte-phase gadoxetic acid-enhanced MR images by focusing on hypervascularization over time. Materials and Methods: In this study, 135 hypovascular nodules revealing no gadoxetic acid uptake in 53 patients were examined. All nodules were retrospectively examined using serial follow-up computed tomography (CT) and MRI examinations until hypervascularity was observed on arterial-phase dynamic CT or gadoxetic acid-enhanced MR images, or on CT during hepatic arteriography. Logistic regression analysis was used to investigate the association between hypervascularization and MR findings including a presence of fat assessed by a signal drop on opposed-phase T1-weighted images. Results: Of the 135 nodules, 16 underwent hypervascularization. The size of the nodules and the presence of fat in the nodules were independent indicators of hypervascularization. The 1-year cumulative risk of hypervascularization was 15.6%. This risk was significantly increased in the case of nodules >10 mm (37.6%, P < 0.01) and fat-containing nodules (26.5%, P < 0.01). Conclusion: Hypovascular nodules that appear hypointense on hepatocyte-phase gadoxetic acid-enhanced MR images may progress to conventional hypervascular hepatocellular carcinoma. Nodules more than 10 mm in diameter and containing fat are at high risk for developing hypervascularization. J. Magn. Reson. Imaging 2011;. © 2011 Wiley-Liss, Inc. |
Databáze: | OpenAIRE |
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