Complex Immunometabolic Profiling Reveals the Activation of Cellular Immunity and Biliary Lesions in Patients with Severe COVID-19
| Autor: | Tomas Vymazal, Josef Zamecnik, Zuzana Parackova, Martin Tulach, Adam Klocperk, Marketa Bloomfield, Anna Sediva, Luis Fernando Casas Mendez, Irena Zentsova, Petra Vrabcova, Grigorij Meseznikov, Jan Balko, Jan Sipek, Alzbeta Grandcourtova |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cellular immunity Pathology medicine.medical_specialty Fulminant T cells lcsh:Medicine Inflammation macromolecular substances Article 03 medical and health sciences Liver disease 0302 clinical medicine Immune system Immunity medicine 030212 general & internal medicine IL-6 business.industry SARS-CoV-2 lcsh:R Acute kidney injury COVID-19 General Medicine medicine.disease Acquired immune system hepatopathy immunity GGT 030104 developmental biology acute kidney injury biliary lesion medicine.symptom liver disease business |
| Zdroj: | Journal of Clinical Medicine, Vol 9, Iss 3000, p 3000 (2020) Journal of Clinical Medicine Volume 9 Issue 9 |
| ISSN: | 2077-0383 |
| Popis: | This study aimed to assess the key laboratory features displayed by coronavirus disease 2019 (COVID-19) inpatients that are associated with mild, moderate, severe, and fatal courses of the disease, and through a longitudinal follow-up, to understand the dynamics of the COVID-19 pathophysiology. All severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-positive patients admitted to the University Hospital in Motol between March and June 2020 were included in this study. A severe course of COVID-19 was associated with an elevation of proinflammatory markers an efflux of immature granulocytes into peripheral blood the activation of CD8 T cells, which infiltrated the lungs transient liver disease. In particular, the elevation of serum gamma-glutamyl transferase (GGT) and histological signs of cholestasis were highly specific for patients with a severe form of the disease. In contrast, patients with a fatal course of COVID-19 failed to upregulate markers of inflammation, showed discoordination of the immune response, and progressed toward acute kidney failure. COVID-19 is a disease with a multi-organ affinity that is characterized by the activation of innate and cellular adaptive immunity. Biliary lesions with an elevation of GGT and the organ infiltration of interleukin 6 (IL-6)-producing cells are the defining characteristics for patients with the fulminant disease. |
| Databáze: | OpenAIRE |
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