Evolution of adaptive immunity from transposable elements combined with innate immune systems
| Autor: | Eugene V. Koonin, Mart Krupovic |
|---|---|
| Přispěvatelé: | National Center for Biotechnology Information (NCBI), Biologie Moléculaire du Gène chez les Extrêmophiles (BMGE), Institut Pasteur [Paris], E.V.K is supported by intramural funds of the US Department of Health and Human Services (to the National Library of Medicine)., The authors thank K. Makarova for critical reading of the manuscript and comments, Institut Pasteur [Paris] (IP) |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
MESH: Immunoglobulins
MESH: V(D)J Recombination [SDV]Life Sciences [q-bio] Molecular Sequence Data Immunoglobulins MESH: Biological Evolution MESH: Escherichia coli Proteins Adaptive Immunity Biology MESH: Base Sequence Article Genome engineering Immune system Molecular evolution Genetics Recombinase Animals Humans CRISPR MESH: Animals Molecular Biology Genetics (clinical) Innate immune system MESH: Molecular Sequence Data MESH: Humans Bacteria Base Sequence Escherichia coli Proteins Acquired immune system Archaea Biological Evolution Immunity Innate V(D)J Recombination MESH: Bacteria MESH: DNA Transposable Elements MESH: Archaea DNA Transposable Elements [SDV.IMM]Life Sciences [q-bio]/Immunology MESH: Immunity Innate Mobile genetic elements MESH: Adaptive Immunity |
| Zdroj: | Nature Reviews Genetics Nature Reviews Genetics, Nature Publishing Group, 2015, 16 (3), pp.184-192. ⟨10.1038/nrg3859⟩ Nature Reviews Genetics, 2015, 16 (3), pp.184-192. ⟨10.1038/nrg3859⟩ |
| ISSN: | 1471-0056 1471-0064 |
| DOI: | 10.1038/nrg3859⟩ |
| Popis: | International audience; Adaptive immune systems in prokaryotes and animals give rise to long-term memory through modification of specific genomic loci, such as by insertion of foreign (viral or plasmid) DNA fragments into clustered regularly interspaced short palindromic repeat (CRISPR) loci in prokaryotes and by V(D)J recombination of immunoglobulin genes in vertebrates. Strikingly, recombinases derived from unrelated mobile genetic elements have essential roles in both prokaryotic and vertebrate adaptive immune systems. Mobile elements, which are ubiquitous in cellular life forms, provide the only known, naturally evolved tools for genome engineering that are successfully adopted by both innate immune systems and genome-editing technologies. In this Opinion article, we present a general scenario for the origin of adaptive immunity from mobile elements and innate immune systems. |
| Databáze: | OpenAIRE |
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