Deacetylation of Miro1 by HDAC6 blocks mitochondrial transport and mediates axon growth inhibition

Autor:	Sharmina Miller-Randolph, Andrew P. Tosolini, Ryan Passino, Victor Wong, Giampietro Schiavo, Leif A. Havton, Roman J. Giger, James N. Sleigh, Amar N. Kar, Alicia L. Hawthorne, Paul Brito-Vargas, Cristina Picci, Seung Joon Lee, Jeffery L. Twiss, Deanna S. Smith, Brett Langley, John Craver, Liang Shi, Ashley L. Kalinski, Dianna E. Willis
Rok vydání:	2017
Předmět:	Male rho GTP-Binding Proteins RHOA Primary Cell Culture Mitochondrion Biology Histone Deacetylase 6 Axonal Transport Motor protein Rats Sprague-Dawley 03 medical and health sciences Mice 0302 clinical medicine Ganglia Spinal Commentaries medicine Animals Axon Spotlight Mitochondrial transport 030304 developmental biology Neurons 0303 health sciences rho-Associated Kinases Acetylation Cell Biology HDAC6 Cell biology Mitochondria Rats Mice Inbred C57BL Myelin-Associated Glycoprotein medicine.anatomical_structure nervous system Chondroitin Sulfate Proteoglycans Gene Expression Regulation biology.protein Calcium Female 030217 neurology & neurosurgery Intracellular Signal Transduction
Zdroj:	The Journal of Cell Biology
ISSN:	1540-8140
Popis:	Van Den Bosch highlights the discovery by Kalinski et al. of Miro1 as an HDAC6 substrate that regulates mitochondrial trafficking in neurons and axon regeneration. Myelin-associated glycoprotein and chondroitin sulfate proteoglycans in the extracellular matrix can prevent regeneration of injured axons. In this issue, Kalinski et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201702187) report that inhibition of HDAC6 prevents the deacetylation of Miro1, increases mitochondrial axonal transport, and restores the size of axonal growth cones.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bff5989a1a5873efca49b789a2a6bef1 https://pubmed.ncbi.nlm.nih.gov/31118238 Zobrazit plný text záznamu