Aureochaeglobosins A–C, Three [4 + 2] Adducts of Chaetoglobosin and Aureonitol Derivatives from Chaetomium globosum
| Autor: | Mei-Ling Gu, Chao Han, Pei Yu, Xiao-Jiang Guo, Ling-Yi Kong, Ming-Hua Yang, Guo-Ping Yin |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Chaetoglobosins
Molecular Structure Chaetomium globosum biology Aureonitol 010405 organic chemistry Stereochemistry Chemistry Organic Chemistry Chaetomium Endophytic fungus 010402 general chemistry biology.organism_classification 01 natural sciences Biochemistry Cycloaddition Indole Alkaloids 0104 chemical sciences Adduct Cell Line Tumor Ic50 values Humans Physical and Theoretical Chemistry Furans |
| Zdroj: | Organic Letters. 20:3345-3348 |
| ISSN: | 1523-7052 1523-7060 |
| DOI: | 10.1021/acs.orglett.8b01243 |
| Popis: | Aureochaeglobosins A–C (1–3), three novel [4 + 2] cycloaddition heterodimers of chaetoglobosin and aureonitol derivatives, were obtained from the culture of endophytic fungus Chaetomium globosum, representing the first adduct examples of chaetoglobosins. Their structures were elucidated by extensive spectroscopic analyses, single-crystal X-ray diffraction, and a modified Mosher’s method. Compounds 2 and 3 showed significant cytotoxicities against human MDA-MB-231 cancer cells with IC50 values of 7.6 and 10.8 μM, respectively. |
| Databáze: | OpenAIRE |
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