Interhospital dissemination of KPC-3 producing-Klebsiella pneumoniae ST512. Detection by MALDI-TOF
| Autor: | Jorge Gaitán Pitera, Carmen Román Ortiz, María Ángeles Asencio Egea, María Huertas Vaquero, Noelia Lara Fuella, Rafael Carranza González |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
biology Klebsiella pneumoniae business.industry 030106 microbiology Outbreak Early detection biology.organism_classification beta-Lactamases Klebsiella Infections Microbiology 03 medical and health sciences 0302 clinical medicine Underlying disease Spectrometry Mass Matrix-Assisted Laser Desorption-Ionization Humans Medicine 030212 general & internal medicine business Retrospective Studies |
| Zdroj: | Enfermedades infecciosas y microbiologia clinica (English ed.). 39:83-86 |
| ISSN: | 2529-993X |
| Popis: | Introduction/Objective To describe an outbreak of KPC-3-producing Klebsiella pneumoniae (KPN) and determine the diagnostic efficacy of MALDI-TOF in its detection. Methods Retrospective study of the KPC-3-KPN isolated in 2 hospitals in Ciudad Real. The peak at 11,109 kDa ± 15 was sought in the KPN spectra provided by MALDI-TOF. Results We isolated 156 KPN strains that carried the blaKPC-3 gene, with a unique profile belonging to ST512 (31 strains studied). There was 25% of infected patients, 84% were nosocomial or related to health care and 93% had some underlying disease (31% of exitus in the first month). The detection of the peak showed 90% sensitivity and 100% specificity. Conclusions We detected the clonal spread of a KPN ST512 strain producing KPC-3 in 3 hospitals in Ciudad Real. In addition, we show the profitability of MALDI-TOF in the early detection of KPC-KPN. |
| Databáze: | OpenAIRE |
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