Isotope-selective non-dispersive infrared spectrometry for detection of Helicobacter pylori infection with 13C-urea breath test
| Autor: | S Koletzko, B Koletzko, M Haisch, P Hering, I Seeboth, K Hengels, B Braden |
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| Rok vydání: | 1995 |
| Předmět: |
Adult
Male Helicobacter pylori infection Pathology medicine.medical_specialty Adolescent Spectrophotometry Infrared Stomach Diseases Infrared spectroscopy Mass Spectrometry 13C urea breath test Helicobacter Infections medicine Humans Urea Child Breath test Carbon Isotopes Chromatography medicine.diagnostic_test Isotope Helicobacter pylori business.industry General Medicine H pylori infection Clinical Practice Breath Tests Child Preschool Female business |
| Zdroj: | Lancet (London, England). 345(8955) |
| ISSN: | 0140-6736 |
| Popis: | 13C-urea breath tests were sampled in 51 subjects with an isotope-selective non-dispersive infrared spectrometer (NDIRS) and compared with the results of conventional isotope-ratio mass-spectrometry (IRMS). Delta-over-baseline values of both methods correlated well (r = 0.976 at 15 min and 0.985 at 30 min, both p < 0.0005). With a cut-off for delta-over-baseline values of 5/1000 (i. e., 5 per thousand), both methods correctly classified all 36 Helicobacter-pylori-negative and all 15 H-pylori-positive subjects. All infected subjects had values over 11/1000 in all samples with both methods. NDIRS is of equal value as IRMS for the diagnosis of H pylori infection. Because NDIRS gives on-line results and is easier and cheaper, we consider NDIRS useful for clinical practice. |
| Databáze: | OpenAIRE |
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