Advancements in Assessments of Bio-tissue Engineering and Viable Cell Delivery Matrices Using Bile Acid-based Pharmacological Biotechnologies
| Autor: | Susbin Raj Wagle, Corina Mihaela Ionescu, Edan Johnston, Momir Mikov, Bozica Kovacevic, Hani Al-Salami, Thomas Foster, Daniel Walker, Jacqueline Chester, Melissa Jones, Armin Mooranian |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0303 health sciences
Bioartificial pancreas Computer science General Chemical Engineering Review 02 engineering and technology 021001 nanoscience & nanotechnology Biocompatible material bioartificial organ immunogenic considerations 03 medical and health sciences Artificial organ Chemistry cell microencapsulation Tissue engineering microcapsule analysis in vitro testing General Materials Science Biochemical engineering 0210 nano-technology Bioartificial Organ Viable cell QD1-999 030304 developmental biology |
| Zdroj: | Nanomaterials Nanomaterials, Vol 11, Iss 1861, p 1861 (2021) |
| ISSN: | 2079-4991 |
| DOI: | 10.3390/nano11071861 |
| Popis: | The utilisation of bioartificial organs is of significant interest to many due to their versatility in treating a wide range of disorders. Microencapsulation has a potentially significant role in such organs. In order to utilise microcapsules, accurate characterisation and analysis is required to assess their properties and suitability. Bioartificial organs or transplantable microdevices must also account for immunogenic considerations, which will be discussed in detail. One of the most characterized cases is the investigation into a bioartificial pancreas, including using microencapsulation of islets or other cells, and will be the focus subject of this review. Overall, this review will discuss the traditional and modern technologies which are necessary for the characterisation of properties for transplantable microdevices or organs, summarizing analysis of the microcapsule itself, cells and finally a working organ. Furthermore, immunogenic considerations of such organs are another important aspect which is addressed within this review. The various techniques, methodologies, advantages, and disadvantages will all be discussed. Hence, the purpose of this review is providing an updated examination of all processes for the analysis of a working, biocompatible artificial organ. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|