Platelet Sensitivity in Vitro to the Prostacyclin Analogue Iloprost in Diabetic Patients
| Autor: | Guido Pozza, Alessandra Macagni, Aurelio M. Vicari |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Adult
Male medicine.medical_specialty Platelet Aggregation Endocrinology Diabetes and Metabolism Clinical Biochemistry Vasodilation Prostacyclin In Vitro Techniques Biochemistry Blood cell Endocrinology Diabetes mellitus Internal medicine medicine Humans Platelet Iloprost IC50 Type 1 diabetes business.industry Biochemistry (medical) General Medicine respiratory system musculoskeletal system medicine.disease Epoprostenol Adenosine Diphosphate Diabetes Mellitus Type 1 medicine.anatomical_structure cardiovascular system Female lipids (amino acids peptides and proteins) Collagen business Platelet Aggregation Inhibitors circulatory and respiratory physiology medicine.drug |
| Zdroj: | Hormone and Metabolic Research. 21:616-618 |
| ISSN: | 1439-4286 0018-5043 |
| DOI: | 10.1055/s-2007-1009301 |
| Popis: | Iloprost is a chemically stable analogue of prostacyclin, with similar vasodilator and anti-platelet actions. Platelet sensitivity to the inhibitory action of Iloprost has been tested in vitro. Platelet-rich plasma from six healthy subjects and from six patients with type 1 diabetes mellitus was incubated with different concentrations of Iloprost, and then stimulated with ADP (at threshold aggregating concentration) and collagen 4 micrograms/ml. The half-maximal inhibitory concentration (IC50) of Iloprost was calculated and no differences were found between patients and controls. The results of this study suggest that diabetic patients without complications do not differ from healthy subjects in their platelet sensitivity to Iloprost. |
| Databáze: | OpenAIRE |
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