The relationship between the soluble Klotho protein and the residual renal function among peritoneal dialysis patients

Autor: Eri Takeshima, Takuya Miki, Hiromichi Yoshizawa, Makoto Kuro-o, Taro Sugase, Kazuhiro Shiizaki, Eiji Kusano, Yoshitaka Iwazu, Naoko Otani, Tomoyuki Yamazaki, Chiharu Ito, Osamu Saito, Johanne Pastor, Akihiko Numata, Shigeaki Muto, Tetsu Akimoto, Yuko Watanabe
Rok vydání: 2012
Předmět:
Zdroj: Clinical and Experimental Nephrology. 16:442-447
ISSN: 1437-7799
1342-1751
Popis: Klotho has been investigated as an anti-aging protein that is predominantly expressed in the distal convoluted tubules in the kidneys and in the choroid plexus of the brain. The purpose of the present study was to determine the relationship between the soluble form of Klotho and renal function in chronic peritoneal dialysis (PD) patients, a relationship which remains poorly understood. The soluble Klotho levels in the serum, urine, and peritoneal dialysate obtained from thirty-six PD patients were determined by a sandwich enzyme-linked immunosorbent assay system. The amount of urinary excreted soluble Klotho over 24 h ranged from 1.54 to 1774.4 ng/day (median 303.2 ng/day; interquartile range [IR] 84.1–498.5), while the serum soluble Klotho concentration ranged from 194.4 to 990.4 pg/ml (mean 553.7 ± 210.4 pg/ml). The amount of urinary Klotho excretion was significantly correlated with residual renal function. However, there was no apparent correlation between the serum soluble Klotho levels and the residual renal function. Klotho was also detected in the 24-h dialysate collections. There was a significant correlation between the peritoneal Klotho excretion and the amount of albumin contained in the dialysate collections (r = 0.798, p
Databáze: OpenAIRE
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