Spinal synergy between nonselective cyclooxygenase inhibitors and morphine antinociception in mice
| Autor: | Hugo F. Miranda, Gianni Pinardi, Juan Carlos Prieto |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Male
Narcotics Ketoprofen Naproxen Pain Pharmacology Piroxicam Mice Diclofenac Confidence Intervals medicine Animals Molecular Biology ED50 Pain Measurement Behavior Animal Dose-Response Relationship Drug Morphine biology Chemistry General Neuroscience Anti-Inflammatory Agents Non-Steroidal Drug Synergism Effective dose (pharmacology) Drug Combinations Spinal Cord biology.protein Neurology (clinical) Cyclooxygenase Developmental Biology medicine.drug |
| Zdroj: | Brain Research. 1049:165-170 |
| ISSN: | 0006-8993 |
| DOI: | 10.1016/j.brainres.2005.04.068 |
| Popis: | The antinociception induced by the intrathecal coadministration of combinations of morphine with the nonsteroidal anti-inflammatory drugs (NSAIDs) naproxen, piroxicam, metamizol, diclofenac and ketoprofen was studied by isobolographic analysis in the acetic acid writhing test of mice. The effective dose that produced 50% antinociception (ED(50)) was calculated from the log dose-response curve of intrathecally administered fixed ratio combinations of morphine with each NSAID. By isobolographic analysis, this ED(50) was compared to the theoretical additive ED(50) calculated from the ED(50) of morphine and of each NSAID alone. As shown by isobolograms, all the combinations were synergistic, the experimental ED(50)'s being significantly smaller than the theoretically calculated ED(50)'s. The results of this study demonstrate potent interactions between morphine and NSAIDs and validate the clinical use of the combinations of opioids and NSAIDs in pain treatment, even by the intrathecal route. |
| Databáze: | OpenAIRE |
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