Inhibition of haptoglobin binding with hemoglobin in the rat at the onset of an inflammatory reaction
| Autor: | M.F Jayle, Janiaud P, Engler R, Degrelle H, Domingo M |
|---|---|
| Rok vydání: | 1969 |
| Předmět: |
Male
Time Factors Chemical Phenomena Turpentine Clinical Biochemistry Biochemistry Chromatography DEAE-Cellulose Hemoglobins polycyclic compounds Animals Antigens skin and connective tissue diseases Immunoelectrophoresis Inflammation Haptoglobin binding Chromatography biology Haptoglobins Chemistry Immune Sera Biochemistry (medical) Haptoglobin food and beverages General Medicine Blood Protein Electrophoresis Rats biology.protein Hemoglobin Rabbits Protein Binding |
| Zdroj: | Clinica chimica acta; international journal of clinical chemistry. 26(3) |
| ISSN: | 0009-8981 |
| Popis: | Six hours after injection of turpentine, the haptoglobin index drops to zero in rat serum. Nevertheless, electrophoretic and immunoelectrophoretic studies allow to demonstrate the presence of haptoglobin in this serum. Haptoglobin recovers its hemoglobin-binding capacity after chromatography of the serum through a DEAE cellulose column. It is suggested that, when Hp is combined with an inhibitor I, according to the reaction I + Hp → I-Hp, Hp cannot combine with Hb. |
| Databáze: | OpenAIRE |
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