Predictive value of a series of inflammatory markers in COPD for lung cancer diagnosis: a case-control study
| Autor: | Alberto Fernández-Villar, Alberto Ruano-Ravina, Maribel Botana-Rial, Cecilia Mouronte-Roibás, Esmeralda García-Rodríguez, Pedro Casado-Rey, Cristina Ramos-Hernández, Virginia Leiro-Fernández |
|---|---|
| Přispěvatelé: | Universidade de Santiago de Compostela. Departamento de Psiquiatría, Radioloxía, Saúde Pública, Enfermaría e Medicina |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Lung Neoplasms Neutrophils Gastroenterology 03 medical and health sciences Pulmonary Disease Chronic Obstructive 0302 clinical medicine Predictive Value of Tests Internal medicine Medicine Humans COPD Mean platelet volume Lung cancer Aged lcsh:RC705-779 Inflammation Framingham Risk Score Receiver operating characteristic business.industry Research Case-control study Area under the curve lcsh:Diseases of the respiratory system Middle Aged medicine.disease Comorbidity respiratory tract diseases 030104 developmental biology Cholesterol 030228 respiratory system Spirometry Case-Control Studies Female Inflammation Mediators business A1AT Biomarkers |
| Zdroj: | Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela instname Respiratory Research Respiratory Research, Vol 20, Iss 1, Pp 1-10 (2019) |
| Popis: | Background: There is a relationship between Chronic Obstructive Pulmonary Disease (COPD) and the development of lung cancer (LC). The aim of this study is to analyse several blood markers and compare their concentrations in patients with only COPD and LC + COPD. Methods: Case-control study with cases presenting combined LC and COPD and two control groups (patients presenting only COPD and patients presenting only LC). We also included LC patients with descriptive purposes. In both groups, peripheral blood analyses of TNF-α, IL-6, IL-8, total leukocyte, lymphocyte and neutrophil counts, neutrophil-to-lymphocyte ratio, total platelet count, mean platelet volume, platelet-to-lymphocyte ratio, alpha 1-antitripsin (A1AT), IgE, C-reactive protein, fibrinogen, cholesterol and bilirubin were performed. We developed univariate and multivariate analyses of these markers, as well as a risk score variable, and we evaluated its performance through ROC curves. Results: We included 280 patients, 109 cases (LC + COPD), 83 controls (COPD) and 88 LC without COPD. No differences were observed in the distribution by sex, age, BMI, smoking, occupational exposure, lung function, GOLD stage or comorbidity. Patients with LC + COPD had significantly higher levels of neutrophils [OR 1.00 (95%CI 1.00–1.00), p = 0.03] and A1AT [OR 1.02 (95%CI 1.01–1.03), p = 0.003] and lower cholesterol levels [OR 0.98 (95%CI 0.97–0.99), p = 0.009] than COPD controls. We developed a risk score variable combining neutrophils, A1AT and cholesterol, achieving a sensitivity of 80%, a negative predictive value of 90.7% and an area under the curve of 0.78 (95%CI 0.71–0.86). Conclusions: COPD patients who also have LC have higher levels of neutrophils and A1AT and lower of cholesterol. These parameters could be potentially predicting biomarkers of LC in COPD patients. This work was supported by the project 110/2016 of the Spanish Society of Respiratory Pathology (SEPAR) SI |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|