Temporal Association of Cannabis Use with Symptoms in Individuals at Clinical High Risk for Psychosis
| Autor: | Victoria L. Cressman, Shamir Khan, Arielle D. Stanford, Dolores Malaspina, Judy L. Thompson, David Kimhy, Cheryl Corcoran, Tiziano Colibazzi, Jill M. Harkavy-Friedman, Scott A. Schobel, Ray Goetz, Julie Walsh |
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| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Drug
Adult Male Psychosis medicine.medical_specialty Marijuana Abuse media_common.quotation_subject Comorbidity Severity of Illness Index Article Prodrome Perceptual Disorders Risk Factors medicine Humans Longitudinal Studies Prospective Studies Young adult Risk factor Prospective cohort study Psychiatry Biological Psychiatry media_common Psychiatric Status Rating Scales biology medicine.disease biology.organism_classification Mental health Anxiety Disorders Diagnostic and Statistical Manual of Mental Disorders Psychiatry and Mental health Psychotic Disorders Schizophrenia Female Cannabis Psychology |
| Popis: | Cannabis use is reported to increase the risk for psychosis, but no prospective study has longitudinally examined drug use and symptoms concurrently in clinical high risk cases.We prospectively followed for up to 2 years 32 cases who met research criteria for prodromal psychosis to examine the relationship between substance use and clinical measures.Cases with a baseline history of cannabis use (41%) were older, but did not differ in clinical measures. Longitudinal assessments showed these cases had significantly more perceptual disturbances and worse functioning during epochs of increased cannabis use that were unexplained by concurrent use of other drugs or medications.These data demonstrate that cannabis use may be a risk factor for the exacerbation of subthreshold psychotic symptoms, specifically perceptual disturbances, in high risk cases. |
| Databáze: | OpenAIRE |
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