Phytosterol Esterification is Markedly Decreased in Preterm Infants Receiving Routine Parenteral Nutrition
| Autor: | Chiara Biagetti, Giovanna Verlato, Albano Nicolai, Daniele Pupillo, Alessio Correani, Rita D'Ascenzo, Marina Taus, Manuela Simonato, Paola Cogo, Virgilio P. Carnielli, Adriana Pompilio, Sara Savini |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male 0301 basic medicine Parenteral Nutrition medicine.medical_specialty Clinical chemistry Campesterol Birth weight Biochemistry Plant sterols Gas Chromatography-Mass Spectrometry 03 medical and health sciences chemistry.chemical_compound Gas chromatography–mass spectrometry Internal medicine medicine Humans Parenteral nutrition Preterm infants Sterol metabolism Cholestasis Cholesterol Esterification Female Infant Infant Newborn Infant Premature Phytosterols Premature 030109 nutrition & dietetics Stigmasterol Phytosterol Organic Chemistry Cell Biology Newborn 030104 developmental biology Endocrinology chemistry Lipidology |
| Zdroj: | Lipids. 51:1353-1361 |
| ISSN: | 1558-9307 0024-4201 |
| DOI: | 10.1007/s11745-016-4197-y |
| Popis: | Several studies reported the association between total plasma phytosterol concentrations and the parenteral nutrition-associated cholestasis (PNAC). To date, no data are available on phytosterol esterification in animals and in humans during parenteral nutrition (PN). We measured free and esterified sterols (cholesterol, campesterol, stigmasterol, and sitosterol) plasma concentrations during PN in 16 preterm infants (500–1249 g of birth weight; Preterm-PN), in 11 term infants (Term-PN) and in 12 adults (Adult-PN). Gas chromatography–mass spectrometry was used for measurements. Plasma concentrations of free cholesterol (Free-CHO), free phytosterols (Free-PHY) and esterified phytosterols (Ester-PHY) were not different among the three PN groups. Esterified cholesterol (Ester-CHO) was statistically lower in Preterm-PN than Adult-PN. Preterm-PN had significantly higher Free-CHO/Ester-CHO and Free-PHY/Ester-PHY ratios than Adult-PN (Free-CHO/Ester-CHO: 1.1 ± 0.7 vs. 0.6 ± 0.2; Free-PHY/Ester-PHY: 4.1 ± 2.6 vs. 1.3 ± 0.8; *P |
| Databáze: | OpenAIRE |
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