The Combination of Partial Liquid Ventilation and Inhaled Nitric Oxide in the Severe Oleic Acid Lung Injury Model
| Autor: | Koichi Nakazawa, Tokujiro Uchida, Keisuke Amaha, Kuninori Yokoyama, Koshi Makita |
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| Rok vydání: | 1998 |
| Předmět: |
Pulmonary and Respiratory Medicine
Artificial ventilation Pulmonary Circulation Respiratory rate medicine.medical_treatment Pulmonary Edema Lung injury Nitric Oxide Critical Care and Intensive Care Medicine chemistry.chemical_compound Fraction of inspired oxygen Animals Medicine Tidal volume Fluorocarbons Inhalation Perflubron business.industry Hemodynamics Carbon Dioxide Respiration Artificial Hydrocarbons Brominated Oxygen chemistry Anesthesia Breathing Vascular Resistance Rabbits Cardiology and Cardiovascular Medicine business Oleic Acid |
| Zdroj: | Chest. 113:1658-1666 |
| ISSN: | 0012-3692 |
| DOI: | 10.1378/chest.113.6.1658 |
| Popis: | Study objectives To elucidate the efficacy of the combination of inhaled nitric oxide (NO) and partial liquid ventilation (PLV) in ARDS. Design Prospective, randomized, controlled study. Setting A research laboratory at a university medical center. Subjects Thirty-two rabbits. Interventions Animals were anesthetized and ventilated via tracheostomy (tidal volume=40 mL; respiratory rate=25 breaths/min; fraction of inspired oxygen=0.99). After 0.08 mL/kg (0.071 g/kg) oleic acid was administered via the central venous route, animals were randomly divided into the following four groups depending on the ventilatory mode: (1) Gas ventilation (GV)control group: GV was continued throughout the study; (2) GV-NO group: NO inhalation (10 ppm) was performed under GV; (3) PLV-control group: PLV using perflubron (15 mL/kg) was continued until the end of the study; and (4) PLV-NO group: NO inhalation (10 ppm) was performed under PLV. Measurements and results NO inhalation improved PaO 2 in the PLV-NO group (from 133±20 to 167±23 mm Hg; p=0.0008), but not in the GV-NO group (from 67±6 to 63±9 mm Hg), although pulmonary vascular resistance decreased both in the GV-NO (from 4,604±328 to 4,337±322 dyne·s·cm −5 ; p=0.0116) and the PLV-NO group (from 4,727±665 to 4,112±560 dyne·s·cm −5 ; p=0.0036). (Data were expressed as mean±SEM.) Conclusion PLV augmented the effect of inhaled NO on pulmonary gas exchange. The combination of PLV and NO inhalation could be effective in severe ARDS. |
| Databáze: | OpenAIRE |
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