Satellite glial cells modulate cholinergic transmission between sympathetic neurons

Autor: Wenqi Fu, Susan J. Birren, Surbhi Sona, Joana Enes, Alexander C. Mitchell, Nega Gerard, Marian Haburcak
Rok vydání: 2020
Předmět:
Male
0301 basic medicine
Physiology
Synaptic Transmission
Biochemistry
Nervous System
Rats
Sprague-Dawley
0302 clinical medicine
Animal Cells
Medicine and Health Sciences
Premovement neuronal activity
Cells
Cultured
Neurons
Staining
Neuronal Death
Ganglia
Sympathetic
Multidisciplinary
Cell Death
Neurochemistry
Neurotransmitters
Specimen preparation and treatment
Cholinergic Neurons
Electrophysiology
medicine.anatomical_structure
Cell Processes
Medicine
Female
Cellular Types
Anatomy
Neuroglia
Research Article
Cell type
Programmed cell death
Science
Cholinergics
Neurophysiology
Biology
Neurotransmission
03 medical and health sciences
Developmental Neuroscience
medicine
Animals
DAPI staining
Biology and Life Sciences
Cell Biology
Neuronal Dendrites
biology.organism_classification
Rats
Research and analysis methods
Biological Tissue
030104 developmental biology
Nerve growth factor
nervous system
Cellular Neuroscience
Synapses
Nuclear staining
Cholinergic
Ganglia
Satellite (biology)
Neuron
Neuroscience
030217 neurology & neurosurgery
Zdroj: PLoS ONE, Vol 15, Iss 2, p e0218643 (2020)
PLoS ONE
ISSN: 1932-6203
Popis: Postganglionic sympathetic neurons and satellite glial cells are the two major cell types of the peripheral sympathetic ganglia. Sympathetic neurons project to and provide neural control of peripheral organs and have been implicated in human disorders ranging from cardiovascular disease to peripheral neuropathies. Here we show that satellite glia regulate synaptic activity of cultured postnatal sympathetic neurons, providing evidence for local ganglionic control of sympathetic drive. In addition to modulating neuron-to-neuron cholinergic neurotransmission, satellite glia promote synapse formation and contribute to neuronal survival. Examination of the cellular architecture of the rat sympathetic ganglia in vivo shows this regulation of neuronal properties takes place during a developmental period in which neuronal morphology and density are actively changing and satellite glia enwrap sympathetic neuronal somata. Cultured satellite glia make and release factors that promote neuronal activity and that can partially rescue the neurons from cell death following nerve growth factor deprivation. Thus, satellite glia play an early and ongoing role within the postnatal sympathetic ganglia, expanding our understanding of the contributions of local and target-derived factors in the regulation of sympathetic neuron function.
Databáze: OpenAIRE
Externí odkaz: