Ten-year experience of Q fever endocarditis in a tertiary cardiac center in Saudi Arabia
| Autor: | N. Kaabia, Khalid Alnajashi, Rashed Albalawi, Didier Raoult, Maaz Akhtar, Nisreen Alsherbeeni, Syed Mehdi, Ahmed M. Alzahrani, Fatehi Elzein, Eid Alsufyani, Ahmed Albarrag |
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| Přispěvatelé: | Microbes évolution phylogénie et infections (MEPHI), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Institut Hospitalier Universitaire Méditerranée Infection (IHU Marseille) |
| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Heart disease Medical Records Tertiary Care Centers 0302 clinical medicine Risk Factors [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases Jugular vein 030212 general & internal medicine Child ComputingMilieux_MISCELLANEOUS Cause of death [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases education.field_of_study General Medicine Middle Aged Anti-Bacterial Agents 3. Good health Infectious Diseases Doxycycline Infective endocarditis [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology Female Q Fever Hydroxychloroquine medicine.drug Adult Microbiology (medical) medicine.medical_specialty Adolescent Heart Diseases 030106 microbiology Population Saudi Arabia Q fever lcsh:Infectious and parasitic diseases Young Adult 03 medical and health sciences [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system Internal medicine medicine Humans Endocarditis lcsh:RC109-216 [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology education Retrospective Studies business.industry Endocarditis Bacterial medicine.disease [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology Jugular Veins business |
| Zdroj: | International Journal of Infectious Diseases International Journal of Infectious Diseases, 2019, 88, pp.21-26. ⟨10.1016/j.ijid.2019.07.035⟩ International Journal of Infectious Diseases, Elsevier, 2019, 88, pp.21-26. ⟨10.1016/j.ijid.2019.07.035⟩ International Journal of Infectious Diseases, Vol 88, Iss, Pp 21-26 (2019) |
| ISSN: | 1201-9712 1878-3511 |
| DOI: | 10.1016/j.ijid.2019.07.035 |
| Popis: | Background: Q fever endocarditis (QFE) is considered rare in the Middle East, with only a few cases reported in Saudi Arabia. The aim of this study is to report on the experience of our centre on QFE. Methods: We searched the medical records for cases of QFE at our cardiac center from 2009–2018. Demographic data, clinical features, serology and echocardiography results, treatments, and outcomes were assessed. Results: Five hundred and two cases of infective endocarditis were detected over the 10 years period. Among the 234 patients with blood culture-negative endocarditis (BCNE), 19 (8.10%) had QFE. All patients had a previously diagnosed congenital heart disease except for one patient with rheumatic heart disease. Eleven patients had received a bovine jugular vein-related implant, e.g., a Melody valve (seven patients) or Contegra conduit (four patients). Coinfection was detected in three patients, and immunologic and embolic phenomena were observed in five patients. All patients received a combination of hydroxychloroquine and doxycycline, with good outcomes. Only two patients required surgery while on treatment. Two patients died several months after treatment; the cause of death was not identified. Conclusion: This study indicates that Q fever exists in our population. The majority of the patients had congenital heart disease (CHD) and underwent bovine jugular vein implants. Patients with CHD are at increased risk of infective endocarditis. Bovine jugular vein implants increase the risk of infective and possibly QFE. Proper exclusion of Q fever is warranted in all BCNE and possibly in culture-positive endocarditis cases in areas endemic to Q fever. Key points: We presented the largest series of Q fever endocarditis cases in Saudi Arabia. We showed that Q fever is not rare in the Middle East and suggest that it should be considered in all blood culture-negative endocarditis cases. Keywords: Q fever endocarditis, Congenital heart disease, Jugular vein, Middle East |
| Databáze: | OpenAIRE |
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