Input-dependent modulation of MEG gamma oscillations reflects gain control in the visual cortex
| Autor: | Justin F. Schneiderman, Elena V. Orekhova, Olga V. Sysoeva, Christopher Gillberg, Tatiana A. Stroganova, Sebastian Lundström, Dzerasa E. Goiaeva, Andrey O. Prokofyev, Courtney Keeler, Bushra Riaz, Ilia A. Galuta, Nouchine Hadjikhani |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male 0301 basic medicine Adolescent Photic Stimulation lcsh:Medicine Stimulation Inhibitory postsynaptic potential Article Young Adult 03 medical and health sciences 0302 clinical medicine medicine Gamma Rhythm Humans Automatic gain control Child lcsh:Science Visual Cortex Physics Multidisciplinary medicine.diagnostic_test lcsh:R Magnetoencephalography Power (physics) Intensity (physics) 030104 developmental biology Visual cortex medicine.anatomical_structure Modulation Female lcsh:Q Neuroscience Excitation 030217 neurology & neurosurgery |
| Zdroj: | Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018) Scientific Reports |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-018-26779-6 |
| Popis: | Gamma-band oscillations arise from the interplay between neural excitation (E) and inhibition (I) and may provide a non-invasive window into the state of cortical circuitry. A bell-shaped modulation of gamma response power by increasing the intensity of sensory input was observed in animals and is thought to reflect neural gain control. Here we sought to find a similar input-output relationship in humans with MEG via modulating the intensity of a visual stimulation by changing the velocity/temporal-frequency of visual motion.In the first experiment, adult participants observed static and moving gratings. The frequency of the MEG gamma response monotonically increased with motion velocity whereas power followed a bell-shape. In the second experiment, on a large group of children and adults, we found that despite drastic developmental changes in frequency and power of gamma oscillations, the relative suppression at high motion velocities was scaled to the same range of values across the life-span.In light of animal and modeling studies, the modulation of gamma power and frequency at high stimulation intensities characterizes the capacity of inhibitory neurons to counterbalance increasing excitation in visual networks. Gamma suppression may thus provide a non-invasive measure of inhibitory-based gain control in the healthy and diseased brain. |
| Databáze: | OpenAIRE |
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