Abnormal IgG cardiolipin antibody titers in patients with Raynaud's phenomenon and/or related disorders: prevalence and clinical significance
| Autor: | Jean Pierre Gaitz, Michel Vayssairat, Nisen Abuaf, Nathalie Baudot, Antoine Deschamps |
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| Rok vydání: | 1998 |
| Předmět: |
Male
medicine.medical_specialty Connective tissue Dermatology Gastroenterology Seroepidemiologic Studies Internal medicine Prevalence Medicine Humans Clinical significance Chilblains Acrocyanosis biology business.industry Vascular disease Undifferentiated connective tissue disease Raynaud Disease Middle Aged medicine.disease Connective tissue disease medicine.anatomical_structure Antibodies Anticardiolipin Case-Control Studies Immunology biology.protein Female Antibody business |
| Zdroj: | Journal of the American Academy of Dermatology. 38(4) |
| ISSN: | 0190-9622 |
| Popis: | Background: The prevalence of antibodies to cardiolipin (a-CL) in patients with Raynaud's phenomenon (RP) and/or related disorders (rD) is not known. Objective: The purpose of this study was to determine the prevalence of these antibodies. Methods: We assayed IgG a-CL in 230 consecutive patients with RP/rD and compared the results with those in a series of 230 control blood donors. Results: Sixteen percent of patients were a-CL positive versus 7.8% of the control donors ( p = 0.014). The prevalence of a-CL positivity was 8.7% for primary RP, 10.5% for secondary RP, 8% for chilblains, 25% for essential acrocyanosis, 20% for connective tissue diseases, and 17% for undifferentiated connective tissue diseases. Among patients with digital necrosis, 24% were a-CL positive. Conclusion: The prevalence of abnormal a-CL titers is higher in patients with RP/rD than in control donors, especially in patients with a connective tissue disease. (J Am Acad Dermatol 1998;38:555-8.) |
| Databáze: | OpenAIRE |
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