The Effect of Phenyramidol on Neural Development in Early Chicken Embryo Model
| Autor: | Gizem Cakici, Ihsan Dogan, Gokmen Kahilogullari, Burak Bahadir, Irem Kar, Agahan Unlu, Eyyub S. M. Al-Beyati, Serhat Aktan, Onur Ozgural, Umit Eroglu |
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| Přispěvatelé: | Ege Üniversitesi |
| Rok vydání: | 2019 |
| Předmět: |
Neural Tube
animal structures Dose Myorelaxant drug Pyridines Embryonic Development Chick Embryo Phenyramidol 0-Belirlenecek Andrology Undeveloped embryo medicine Animals Neural Tube Defects Incubation business.industry Muscle Relaxants Central Neural tube [No Keywords] Embryo Neural tube defect Chicken embryo Growth retardation medicine.anatomical_structure embryonic structures Surgery Neurology (clinical) business Neural development Chickens |
| Zdroj: | Turkish neurosurgery. 29(6) |
| ISSN: | 1019-5149 |
| Popis: | PubMed: 31192442 2-s2.0-85075805534 AIM: To investigate the effects of Phenyramidol (Phe) on neural development in an early chicken embryo model. MATERIAL and METHODS: Sixty fertile non-pathogenic Super Nick eggs were incubated for 24 hours (h) and divided into four groups of 15 eggs each. Phe was administrated through the sub-blastoderm, and the eggs were incubated for another 24 h. All eggs were opened after 48 h of incubation, and the embryos were evaluated morphologically and histopathologically. RESULTS: In Group 1 (control group), none exhibited neural tube defects (NTDs) (0%), 1 (6.6%) was undeveloped; in Group 2 (low dosages), 1 did not develop (6.6%); in Group 3 (normal dosages), 2 (13.4%) had NTDs, 1 (6.6%) was undeveloped; in Group 4 (high dosages), 5 (33.3%) had NTDs, 2 (13.3%) were undeveloped. CONCLUSION: In light of the results, it was determined that the use of increasing doses of Phe led to defects in midline closure in early chicken embryos. This is the first report in the literature on Phe used in an early chicken embryo model. © 2019, Turkish Neurosurgical Society. Preparation for publication of this article is partly supported by Turkish Neurosurgical Society. |
| Databáze: | OpenAIRE |
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