Amorphous Drug-PVP Dispersions: Application of Theoretical, Thermal and Spectroscopic Analytical Techniques to the Study of a Molecule With Intermolecular Bonds in Both the Crystalline and Pure Amorphous State
| Autor: | Michael G. Fakes, Andrew B. Dennis, Peter Timmins, Gary McGeorge, Chhaya Patel, John F. Gamble, Jonathan Brown, Shawn X. Yin, Yaroslav Z. Khimyak, Mike Tobyn, Gao Qi, Wayne Sinclair |
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| Rok vydání: | 2009 |
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Indoles
Magnetic Resonance Spectroscopy Analytical chemistry Pharmaceutical Science Infrared spectroscopy Spectrum Analysis Raman Phase Transition Piperazines law.invention symbols.namesake Drug Stability HIV Fusion Inhibitors law Pyruvic Acid Spectroscopy Fourier Transform Infrared Molecule Crystallization Calorimetry Differential Scanning Hydrogen bond Chemistry Intermolecular force technology industry and agriculture Povidone Amorphous solid Solubility symbols Physical chemistry Glass transition Raman spectroscopy |
| Zdroj: | Journal of Pharmaceutical Sciences. 98:3456-3468 |
| ISSN: | 0022-3549 |
| DOI: | 10.1002/jps.21738 |
| Popis: | We report the case of BMS-488043-PVP solid dispersions which when analysed using modulated DSC showed compliance with the Gordon–Taylor model, confirming ideal mixing behaviour of the two components. The nature or presence of stabilising interactions between drug and PVP could not be confirmed using this technique. Use of FT-IR, Raman and solid-state NMR spectroscopy confirmed the presence of stabilising hydrogen bond interactions between the drug and PVP. Similar interactions are present as intermolecular bonds in the crystalline and pure amorphous drug system. The Gordon–Taylor equation, as it is not predictive of the presence of intermolecular bonds such as hydrogen bonding in an amorphous dispersion, may underestimate the likely physical stability of solid dispersions which are produced and stabilised by these interactions. © 2009 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 98:3456–3468, 2009 |
| Databáze: | OpenAIRE |
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