T-Cell Responses before and after the Fifth Consecutive Acellular Pertussis Vaccination in 4-Year-Old Dutch Children
| Autor: | Anne-Marie Buisman, Rose-Minke Schure, Lotte H. Hendrikx, Elisabeth A. M. Sanders, Lia G. H. de Rond, Kemal Öztürk, Guy A. M. Berbers |
|---|---|
| Přispěvatelé: | Pediatric surgery, CCA - Innovative therapy |
| Rok vydání: | 2012 |
| Předmět: |
Microbiology (medical)
Bordetella pertussis Clinical Biochemistry Immunology Booster dose Immunoglobulin E Interferon-gamma Th2 Cells Vaccines Acellular medicine Humans Immunology and Allergy Child Netherlands Pertussis Vaccine Vaccines Booster (rocketry) biology business.industry Diphtheria Vaccination Infant Th1 Cells medicine.disease biology.organism_classification Antibodies Bacterial Interleukin-10 Cross-Sectional Studies Immunization Child Preschool biology.protein Th17 Cells Pertussis vaccine business medicine.drug |
| Zdroj: | Schure, R M, Hendrikx, L H, de Rond, L G H, Ozturk, K, Sanders, E A M, Berbers, G A M & Buisman, A M 2012, ' T-Cell Responses before and after the Fifth Consecutive Acellular Pertussis Vaccination in 4-Year-Old Dutch Children ', Clinical and Vaccine Immunology, vol. 19, no. 11, pp. 1879-1886 . https://doi.org/10.1128/CVI.00277-12 Clinical and Vaccine Immunology, 19(11), 1879-1886. American Society for Microbiology |
| ISSN: | 1556-679X 1556-6811 |
| Popis: | Immunization with acellular pertussis vaccine (aP) induces higher specific antibody levels and fewer adverse reactions than does immunization with the whole-cell vaccine (wP). However, antibody levels in infants induced by both types of pertussis vaccines wane already after 1 year. Therefore, long-term T-cell responses upon vaccination might play a role in protection against pertussis. In a cross-sectional study (ISRCTN65428640), we investigated T-helper (Th) cell immune responses in wP- or aP-vaccinated children before and after an aP low-dose or high-dose preschool booster at 4 years of age in The Netherlands. T cells were stimulated with pertussis vaccine antigens. The numbers of gamma interferon-producing cells and Th1, Th2, Th17, and interleukin-10 (IL-10) cytokine concentrations were determined. In addition, pertussis-specific IgE levels were measured in plasma. Children being vaccinated with aP vaccinations at 2, 3, 4, and 11 months of age still showed higher pertussis-specific T-cell responses at 4 years of age than did wP-vaccinated children. These T-cell responses failed to show a typical increase in cytokine production after a fifth aP vaccination but remained high after a low-dose booster and seemed to decline even after a high-dose booster. Importantly, elevated IgE levels were induced after this booster vaccination. In contrast, wP-vaccinated children had only low prebooster T-cell responses, and these children showed a clear postbooster T-cell memory response even after a low-dose booster vaccine. Four high-dose aP vaccinations in infancy induce high T-cell responses still present even 3 years after vaccination and enhanced IgE responses after preschool booster vaccination. Therefore, studies of changes in vaccine dosage, timing of pertussis (booster) vaccinations, and the possible association with local side effects are necessary. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|