Effects of anti-interleukin 6 on inflammatory responses during murine septic peritonitis
| Autor: | T. van der Poll, W. A. Buurman, C. V. Keogh, D. Helfgott, S. F. Lowry, L. Berman |
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| Přispěvatelé: | Center of Experimental and Molecular Medicine |
| Jazyk: | angličtina |
| Rok vydání: | 1996 |
| Předmět: |
0301 basic medicine
biology business.industry 030106 microbiology Immunology Acute-phase protein Interleukin Peritonitis Cell Biology medicine.disease Microbiology Pathogenesis Systemic inflammatory response syndrome Sepsis 03 medical and health sciences 0302 clinical medicine Infectious Diseases medicine biology.protein Tumor necrosis factor alpha business Interleukin 6 Molecular Biology 030215 immunology |
| Zdroj: | Journal of endotoxin research, 3(6), 463-470. Maney Publishing Innate immunity, 3(6), 463-470. SAGE Publications Ltd |
| ISSN: | 0968-0519 1753-4259 |
| Popis: | Interleukin (IL)-6 has a limited role in the pathogenesis of the acute systemic inflammatory response syndrome elicited by bolus administration of bacteria or bacterial products. We sought to determine the role of IL-6 in septic peritonitis induced by cecal ligation and puncture (CLP). CLP led to a rapid and sustained induction of IL-6 in plasma and organ homogenates. Pretreatment (-2 h) with an anti-IL-6 mAb (1 mg) resulted in higher plasma and hepatic levels of tumor necrosis factor (TNF), as well as higher plasma concentrations of soluble TNF receptors and IL-10, while attenuating the acute phase protein response. Administration of anti-IL-6 did not influence survival. These results suggest that IL-6 production during septic peritonitis serves to inhibit the appearance of both agonist and antagonist members of the cytokine network. The importance of IL-6 in mediating the cytokine response to infection may be underestimated in more acute sepsis models. |
| Databáze: | OpenAIRE |
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