| Autor: |
Don W. Coulter, Shantaram S. Joshi, Hamid Band, J. Graham Sharp, Timothy R. McGuire, Yutong Liu, Sutapa Ray, Erin M. McIntyre, Mamta Shukla, Varun Kesherwani, Connor N. Griggs, Matthew J. Kling, Nagendra K. Chaturvedi |
| Rok vydání: |
2023 |
| Popis: |
Fig. S1. RNA-seq analysis between MYC vs non-MYC amplified MB cell lines. Fig. S2. Synergistic effects of OTX and mTOR inhibitors on MYC-amplified MB cell growth. Fig. S3. JQ1 chemosensitizes the MB cells. Fig. S4. Flow cytometry plots for cell cycle distribution (as summarized in main Fig. 2A and 2D) in MB cell lines-treated with inhibitors alone or combined as indicated. Fig. S5. The representative Annexin-V flow plots for apoptosis (as summarized in main Fig. 2C and 2E) in HD-MB03 MB cell lines-treated with inhibitors alone or combined as indicated. Fig. S6. Combination effects of BET protein inhibitor OTX with mTOR inhibitors (BEZ/TEM) on cell cycle and apoptosis in MYC-driven HD-MB03 cells. Fig. S7. Combination effects of JQ1/BEZ or JQ1/TEM on associated pathways/molecules. Fig. S8. Effects of inhibitors on body weight and histology of the MB xenograft mice. Fig. S9. Combined in vivo effects of JQ1 and BEZ on the expression levels of target key proteins using subcutaneous MYC-amplified MB xenografts. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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