Role of Perioperative Pregabalin in the Management of Acute and Chronic Post-Thoracotomy Pain
| Autor: | Sara Gaber, Mohamed Naguib Abdel Fattah, Mohamed El-Ramly, Emad G. Saleh, Rafaat Reyad, Somaya M. Elshaikh, Ismail A. Mourad |
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| Rok vydání: | 2019 |
| Předmět: |
Visual analogue scale
medicine.medical_treatment Pregabalin lcsh:Medicine 030209 endocrinology & metabolism Neuropathic pain 03 medical and health sciences 0302 clinical medicine medicine Post-thoracotomy pain syndrome 030212 general & internal medicine Thoracotomy Thoracic tumour business.industry lcsh:R General Medicine Perioperative Clinical Science Allodynia Anesthesia Hyperalgesia Morphine medicine.symptom business medicine.drug |
| Zdroj: | Open Access Macedonian Journal of Medical Sciences Open Access Macedonian Journal of Medical Sciences, Vol 7, Iss 12 (2019) Open Access Macedonian Journal of Medical Sciences; Vol 7 No 12 (2019): Jun 30 (OAMJMS); 1974-1978 |
| ISSN: | 1857-9655 |
| Popis: | BACKGROUND: Post-thoracotomy pain syndrome (PTPS) can be challenging to treat. AIM: This study aimed to evaluate the efficacy of perioperative pregabalin in the prevention of acute and chronic post-thoracotomy pain. METHODS: Sixty patients scheduled for thoracotomy for oncologic surgeries were randomly allocated to one of two groups; Pregabalin and Control. In the Pregabalin group, pregabalin 150 mg was administered one hour before thoracotomy and 12 hours later, then every 12 hours for five days. Pain intensity was assessed using the Visual Analogue Scale (VAS) at rest (VAS-R) and dynamic (VAS-D) in the ICU and during the next four days. Morphine consumption and the frequency of side effects were recorded. Assessment of PTPS was done using the Leeds Assessment of Neuropathic Symptoms and Signs (LANSS) scale at 1, 2, and 3 months. RESULTS: The VAS-R and VAS-D scores and the total morphine consumption were significantly lower in Pregabalin group during days 0 through 4. Neuropathic pain, allodynia, and hyperalgesia were significantly lower in Pregabalin group after 1, 2, and 3 months. CONCLUSION: Pregabalin is effective in the reduction of chronic neuropathic pain at 1, 2, and 3 months after thoracotomy and it also reduces pain and opioid consumption during the acute postoperative period with few adverse effects. |
| Databáze: | OpenAIRE |
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