Spontaneous quantal and non-quantal release of acetylcholine at mouse endplate during onset of hypoxia

Autor:	E A, Bukharaeva, R I, Salakhutdinov, F, Vyskocil, E E, Nikolsky
Rok vydání:	2005
Předmět:	Male Mice Physiology Muscle Fibers Skeletal Action Potentials Animals General Medicine In Vitro Techniques Motor Endplate Acetylcholine Cell Hypoxia Membrane Potentials
Zdroj:	Physiological Research. :251-255
ISSN:	1802-9973 0862-8408
Popis:	At 20 (0)C, both quantal and non-quantal spontaneous acetylcholine release (expressed as miniature endplate potential frequency [f-MEPPs] and the H-effect, respectively) increased during the first 30 min of hypoxia in solution with normal extracellular calcium ([Ca(2+)](o) = 2.0 mM). The hypoxia-induced tenfold increase of the f-MEPPs was virtually absent in low calcium solution([Ca(2+)](o) = 0.4 mM) whereas there was still a significant increment of non-quantal release. This indicates that each of these two processes of acetylcholine release is influenced by mechanisms with different oxygen sensitivity. The rise of f-MEPPs during the onset of hypoxia apparently requires Ca(2+) entry into the nerve terminal, whereas the non-quantal release can be increased by another factors such as a lower level of ATP.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfda8c9d14c4b45e29b3f6f50918e379 https://doi.org/10.33549/physiolres.930718 Zobrazit plný text záznamu