Ruthenium Complexes with 2-Pyridin-2-yl-1H-benzimidazole as Potential Antimicrobial Agents: Correlation between Chemical Properties and Anti-Biofilm Effects

Autor: Patrycja Rogala, Marcin Drabik, Agnieszka Jabłońska-Wawrzycka, Grzegorz Czerwonka, Katarzyna Gałczyńska, Magdalena Dańczuk
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Pyridines
Drug Evaluation
Preclinical
Electrochemistry
Ligands
chemistry.chemical_compound
Anti-Infective Agents
Coordination Complexes
Zeta potential
Biology (General)
contact angle
Spectroscopy
Biological activity
General Medicine
Hydrogen-Ion Concentration
Antimicrobial
Computer Science Applications
Ruthenium
Chemistry
Pseudomonas aeruginosa
Benzimidazole
Staphylococcus aureus
Cell Survival
Surface Properties
QH301-705.5
chemistry.chemical_element
Microbial Sensitivity Tests
Catalysis
Article
Cell Line
Inorganic Chemistry
zeta potential
Escherichia coli
ruthenium complexes
Humans
Hirshfeld surface analysis
Physical and Theoretical Chemistry
Molecular Biology
QD1-999
Ligand
Organic Chemistry
Biofilm
Combinatorial chemistry
Oxygen
Kinetics
adhesion study
chemistry
electrochemistry
Biofilms
Drug Design
Benzimidazoles
antibacterial and anti-biofilm activity
Zdroj: International Journal of Molecular Sciences, Vol 22, Iss 10113, p 10113 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 18
ISSN: 1661-6596
1422-0067
Popis: Antimicrobial resistance is a growing public health concern that requires urgent action. Biofilm-associated resistance to antimicrobials begins at the attachment phase and increases as the biofilms maturate. Hence, interrupting the initial binding process of bacteria to surfaces is essential to effectively prevent biofilm-associated problems. Herein, we have evaluated the antibacterial and anti-biofilm activities of three ruthenium complexes in different oxidation states with 2-pyridin-2-yl-1H-benzimidazole (L1 = 2,2′-PyBIm): [(η6-p-cymene)RuIIClL1]PF6 (Ru(II) complex), mer-[RuIIICl3(CH3CN)L1]·L1·3H2O (Ru(III) complex), (H2L1)2[RuIIICl4(CH3CN)2]2[RuIVCl4(CH3CN)2]·2Cl·6H2O (Ru(III/IV) complex). The biological activity of the compounds was screened against Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa strains. The results indicated that the anti-biofilm activity of the Ru complexes at concentration of 1 mM was better than that of the ligand alone against the P. aeruginosa PAO1. It means that ligand, in combination with ruthenium ion, shows a synergistic effect. The effect of the Ru complexes on cell surface properties was determined by the contact angle and zeta potential values. The electric and physical properties of the microbial surface are useful tools for the examined aggregation phenomenon and disruption of the adhesion. Considering that intermolecular interactions are important and largely define the functions of compounds, we examined interactions in the crystals of the Ru complexes using the Hirshfeld surface analysis.
Databáze: OpenAIRE
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