The antifibrotic effects of alveolar macrophages 5-HT2C receptors blockade on bleomycin-induced pulmonary fibrosis in rats
| Autor: | Samah M. Elaidy, Soha S. Essawy |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Pathology medicine.medical_specialty Pulmonary Fibrosis Bleomycin Terguride 03 medical and health sciences Idiopathic pulmonary fibrosis chemistry.chemical_compound Fibrosis Macrophages Alveolar Pulmonary fibrosis Receptor Serotonin 5-HT2C medicine Animals Spiro Compounds Rats Wistar Receptor 5-HT receptor Pharmacology Sulfonamides Lung business.industry General Medicine medicine.disease Rats 030104 developmental biology medicine.anatomical_structure chemistry Serotonin Antagonists business medicine.drug |
| Zdroj: | Pharmacological Reports. 68:1244-1253 |
| ISSN: | 1734-1140 |
| DOI: | 10.1016/j.pharep.2016.08.005 |
| Popis: | The most widespread chronic fibrosing lung disease is idiopathic pulmonary fibrosis. Lung serotonin (5-HT) content is increased during pulmonary fibrosis with the implication of 5-HT2 receptors in the pathogenesis. Serotonin plays important roles in alveolar macrophages function through 5-HT2C receptors activation. Numerous studies described the important role of 5-HT2A/B receptor blockers in suppressing different types of fibrosis as idiopathic pulmonary fibrosis. The current study pointed to examine the antifibrotic effects of RS-102221 and/or terguride through in vivo model of pulmonary fibrosis.Induction of pulmonary fibrosis was through a single dose of intra-tracheal bleomycin instillation (5mg/kg dissolved in phosphate buffer saline) in adult male albino Wistar rats. Next day of bleomycin instillation, intraperitoneal injection of RS-102221 (0.5mg/kg/d) and/or terguride (1.2mg/kg/d) were administered and continued for 14 days.Noticeable increase in 5-HT2C receptors expression was observed in fibrotic lung tissues with marked allocation belonging to alveolar macrophages. Either RS-102221 or terguride reduced the increments in lung water contents, grading of lung fibrosis, lung tumor necrosis factor-alpha (TNF-α), transforming growth factor-beta1 (TGF-These findings suggested the potential use of 5-HT2A/B/C antagonists as anti-fibrotic agents in lung fibrosis. |
| Databáze: | OpenAIRE |
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