Brainstem and Cortical Spreading Depolarization in a Closed Head Injury Rat Model

Autor: Daniela Kaufer, Lynn T Yang, Refat Aboghazleh, Ellen Parker, Alon Friedman, Gerben van Hameren, Jens P. Dreier
Rok vydání: 2021
Předmět:
Male
QH301-705.5
Traumatic brain injury
Article
Catalysis
brainstem
Rats
Sprague-Dawley
Inorganic Chemistry
03 medical and health sciences
0302 clinical medicine
Brain Injuries
Traumatic
medicine
Animals
cortical spreading depolarization
oxidative stress
Biology (General)
Physical and Theoretical Chemistry
QD1-999
Molecular Biology
Electrocorticography
Spectroscopy
Depression (differential diagnoses)
electrocorticography
030304 developmental biology
0303 health sciences
medicine.diagnostic_test
business.industry
traumatic brain injury
Cortical Spreading Depression
Organic Chemistry
Depolarization
General Medicine
medicine.disease
Rats
Computer Science Applications
Chemistry
Electrophysiology
Anesthesia
Cortical spreading depression
Closed head injury
Brainstem
business
030217 neurology & neurosurgery
Brain Stem
Zdroj: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 11642, p 11642 (2021)
Volume 22
Issue 21
ISSN: 1422-0067
DOI: 10.3390/ijms222111642
Popis: Traumatic brain injury (TBI) is the leading cause of death in young individuals, and is a major health concern that often leads to long-lasting complications. However, the electrophysiological events that occur immediately after traumatic brain injury, and may underlie impact outcomes, have not been fully elucidated. To investigate the electrophysiological events that immediately follow traumatic brain injury, a weight-drop model of traumatic brain injury was used in rats pre-implanted with epidural and intracerebral electrodes. Electrophysiological (near-direct current) recordings and simultaneous alternating current recordings of brain activity were started within seconds following impact. Cortical spreading depolarization (SD) and SD-induced spreading depression occurred in approximately 50% of mild and severe impacts. SD was recorded within three minutes after injury in either one or both brain hemispheres. Electrographic seizures were rare. While both TBI- and electrically induced SDs resulted in elevated oxidative stress, TBI-exposed brains showed a reduced antioxidant defense. In severe TBI, brainstem SD could be recorded in addition to cortical SD, but this did not lead to the death of the animals. Severe impact, however, led to immediate death in 24% of animals, and was electrocorticographically characterized by non-spreading depression (NSD) of activity followed by terminal SD in both cortex and brainstem.
Databáze: OpenAIRE
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