Point shear-wave elastography in chronic pancreatitis: A promising tool for staging disease severity
| Autor: | Clara Benedetta Conti, Paolo Cantù, I. Parzanese, Alessandra Baccarin, Mirella Fraquelli, R. Rosa, Dario Conte, A. Tenca, R. Pozzi, M. Giunta, Daniele Gridavilla, Giovanni Casella, Giovanni Casazza |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Intraclass correlation Endocrinology Diabetes and Metabolism Gastroenterology 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Internal medicine Pancreatitis Chronic medicine Humans Stage (cooking) Pancreatitis chronic Pancreas Aged Hepatology medicine.diagnostic_test business.industry Liver Diseases Ultrasound Reproducibility of Results Middle Aged medicine.disease medicine.anatomical_structure Pancreatitis Elasticity Imaging Techniques 030211 gastroenterology & hepatology Female Elastography Radiology Transient elastography business |
| Zdroj: | Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]. 17(6) |
| ISSN: | 1424-3911 |
| Popis: | Background Objectives: ElastPQ®-pSWE is an ultrasound technique developed to stage disease severity in patients with chronic liver diseases. Little data is available about its application to the pancreas. We aimed to assess the feasibility and reproducibility of pancreatic stiffness (PS) measurements in patients with chronic pancreatitis and their relationship with clinical and laboratory data. Material and methods 52 consecutive patients with chronic pancreatitis (CP) (40 males; median age 60 years) underwent hepatic and pancreatic pSWE. Liver stiffness was measured by transient elastography, 42 healthy subjects being controls (25 males; median age 54 years). Pancreatic pSWE inter-observer agreement was analyzed by intraclass correlation coefficient (ICC). The effects of clinical, laboratory and US data on PS measurements were evaluated by linear regression. Results pSWE was feasible in all the CP patients, but one. Pancreatic stiffness was significantly higher in CP patients than healthy controls (4.3 ± SD 2.4 vs. 2.8 ± SD 1.1 kPa, respectively, p = 0.001). Significantly higher values in the CP group were observed in patients with longer disease duration (>10 vs. ≤10 years) (5.8 ± SD 4 vs. 3.9 ± SD 1.5 kPa, respectively, p = 0.01), on chronic analgesic drugs (6.0 vs. 3.5 kPa, p Conclusions ElastPQ®-pSWE is promising and reproducible in assessing pancreatic stiffness, which mainly reflects disease length and severity. Accordingly, its use is of potential value in stratifying CP patients by identifying those with a more serious degree of disease. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect