The Chemical Composition of Endotoxin Isolated from Intestinal Strain of Desulfovibrio desulfuricans
| Autor: | Daniel Wolny, Zofia Dzierżewicz, Slawomir Kurkiewicz, Marzena Jaworska-Kik, Ludmiła Węglarz, Jolanta Lodowska |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Lipopolysaccharides
Lipopolysaccharide Article Subject Rhamnose Heptose Mannose lcsh:Medicine lcsh:Technology General Biochemistry Genetics and Molecular Biology Fucose Microbiology Lipid A chemistry.chemical_compound Feces Species Specificity Humans Desulfovibrio desulfuricans lcsh:Science General Environmental Science chemistry.chemical_classification biology lcsh:T lcsh:R General Medicine Oligosaccharide biology.organism_classification Endotoxins Intestines chemistry Biochemistry lcsh:Q Bacteria Research Article |
| Zdroj: | The Scientific World Journal, Vol 2012 (2012) The Scientific World Journal |
| Popis: | Desulfovibrio desulfuricansanaerobes are constituents of human alimentary tract microflora. There are suggestions that they take part in the pathogenesis of periodontitis and some gastrointestinal inflammatory disorders, such as ulcerative colitis or Crohn’s disease. Endotoxin is one of Gram-negative bacteria cellular components that influence these microorganisms pathogenicity. Endotoxin is a lipid-polisaccharide heteropolymer consisting of three elements: lipid A, core oligosaccharide, and O-specific polysaccharide, also called antigen-O. The biological activity of lipopolysaccharide (LPS) is determined by its structure. In this study, we show that rhamnose, fucose, mannose, glucose, galactose, heptose, and 2-keto-3-deoxyoctulosonic acid (Kdo) are constituents ofD. desulfuricansendotoxin oligosaccharide core and O-antigen. Lipid A of these bacteria LPS is composed of glucosamine disaccharide substituted by 3-acyloxyacyl residues: ester-bound 3-(dodecanoyloxy)tetradecanoic, 3-(hexadecanoyloxy)tetradecanoic acid, and amide-bound 3-(tetradecanoyloxy)tetradecanoic acid. |
| Databáze: | OpenAIRE |
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