Targeting the insulin granule for modulation of insulin exocytosis
| Autor: | Sofianos Andrikopoulos, Belinda Yau, Melkam A. Kebede, Samantha L. Hocking |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_treatment
Population Motility Type 2 diabetes Biology Biochemistry Exocytosis Drug Delivery Systems Diabetes mellitus Insulin-Secreting Cells Insulin Secretion medicine Glucose homeostasis Animals Humans Hypoglycemic Agents Insulin Secretion education Pharmacology education.field_of_study virus diseases medicine.disease Cell biology Diabetes Mellitus Type 2 |
| Zdroj: | Biochemical pharmacology. 194 |
| ISSN: | 1873-2968 |
| Popis: | The pancreatic β-cells control insulin secretion in the body to regulate glucose homeostasis, and β-cell stress and dysfunction is characteristic of Type 2 Diabetes. Pharmacological targeting of the β-cell to increase insulin secretion is typically utilised, however, extended use of common drugs such as sulfonylureas are known to result in secondary failure. Moreover, there is evidence they may induce β-cell failure in the long term. Within β-cells, insulin secretory granules (ISG) serve as compartments to store, process and traffic insulin for exocytosis. There is now growing evidence that ISG exist in multiple populations, distinct in their protein composition, motility, age, and capacity for secretion. In this review, we discuss the implications of a heterogenous ISG population in β-cells and highlight the need for more understanding into how unique ISG populations may be targeted in anti-diabetic therapies. |
| Databáze: | OpenAIRE |
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