Neurotrophic activity of honokiol on the cultures of fetal rat cortical neurons
| Autor: | Haifeng Zhai, Ritsuko Yokoyama, Yoshiyasu Fukuyama, Kousuke Nakade, Yuka Minoshima, Yasuhide Mitsumoto |
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| Rok vydání: | 2002 |
| Předmět: |
Honokiol
Neurite Clinical Biochemistry Pharmaceutical Science Pharmacology Pharmacognosy Biochemistry Culture Media Serum-Free Lignans chemistry.chemical_compound Drug Discovery Neurites medicine Animals Molecular Biology Cells Cultured Cerebral Cortex Neurons biology Chemistry Biphenyl Compounds Organic Chemistry Biological activity In vitro Rats Cortex (botany) medicine.anatomical_structure biology.protein Molecular Medicine Neuron Neurotrophin |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 12:1163-1166 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/s0960-894x(02)00112-9 |
| Popis: | Honokiol, a main biphenyl neolignan of the traditional crude medicine, Magnoliae cortex, was found to show neurotrophic activity on the cultures of rat cortical neurons at concentration from 0.1 to 10 μM. In the cortical neurons cultured in serum-free medium supplemented with B27, honokiol could promote neurite outgrowth. In addition, the survival and growth of neurons were significantly enhanced by adding honokiol to the primary cultures in serum-free medium supplemented with N2. Its neurotrophic activity was comparable to 40 ng mL−1 of bFGF at concentration of 10 μM. |
| Databáze: | OpenAIRE |
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