H13 influenza viruses in wild birds have undergone genetic and antigenic diversification in nature
Autor: | Scott Krauss, Richard J. Webby, Keita Matsuno, Masatoshi Okamatsu, Youn-Jeong Lee, Takahiro Hiono, Hiroshi Kida, Zu-Jyun Wang, Yuto Kikutani, Lam Thanh Nguyen, Yoshihiro Sakoda |
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Jazyk: | angličtina |
Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
040301 veterinary sciences viruses animal diseases Group ii Animals Wild Hemagglutinin Glycoproteins Influenza Virus Avian influenza Genome Viral medicine.disease_cause Virus 0403 veterinary science Birds 03 medical and health sciences Antigen Virology H13 subtype Waterfowl medicine Genetics Animals Molecular Biology Antigens Viral Phylogeny biology Strain (biology) virus diseases Genetic Variation Antigenic analysis 04 agricultural and veterinary sciences General Medicine Antigenicity biology.organism_classification Antigenic Variation Influenza A virus subtype H5N1 030104 developmental biology Amino Acid Substitution Influenza A virus Influenza in Birds Mutation RNA Viral Tern |
Zdroj: | Virus Genes. 54(4):543-549 |
ISSN: | 0920-8569 |
Popis: | Among 16 haemagglutinin (HA) subtypes of avian influenza viruses (AIVs), H13 AIVs have rarely been isolated in wild waterfowl. H13 AIVs cause asymptomatic infection and are maintained mainly in gull and tern populations; however, the recorded antigenic information relating to the viruses has been limited. In this study, 2 H13 AIVs, A/duck/Hokkaido/W345/2012 (H13N2) and A/duck/Hokkaido/WZ68/2012 (H13N2), isolated from the same area in the same year in our surveillance, were genetically and antigenically analyzed with 10 representative H13 strains including a prototype strain, A/gull/Maryland/704/1977 (H13N6). The HA genes of H13 AIVs were phylogenetically divided into 3 groups (I, II, and III). A/duck/Hokkaido/W345/2012 (H13N2) was genetically classified into Group III. This virus was distinct from a prototype strain, A/gull/Maryland/704/1977 (H13N6), and the virus, A/duck/Hokkaido/WZ68/2012 (H13N2), both belonging to Group I. Antigenic analysis indicated that the viruses of Group I were antigenically closely related to those of Group II, but distinct from those of Group III, including A/duck/Hokkaido/W345/2012 (H13N2). In summary, our study indicates that H13 AIVs have undergone antigenic diversification in nature. |
Databáze: | OpenAIRE |
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