Chemical Structure and Surface Modification of Dendritic Nanomaterials Tailored for Therapeutic and Diagnostic Applications
| Autor: | Kevin A. Tam, Hao Jui Hsu, Jason Bugno, Ja Hye Myung, Seungpyo Hong |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Dendrimers
Materials science Surface Properties Chemical structure Propylenimine Nanotechnology 02 engineering and technology Gene delivery 01 natural sciences Nanomaterials Drug Delivery Systems Dendrimer Drug Discovery Animals Humans Molecule Diagnostic Techniques and Procedures Molecular Structure 010405 organic chemistry Gene Transfer Techniques General Medicine 021001 nanoscience & nanotechnology Nanostructures 0104 chemical sciences Drug delivery Surface modification 0210 nano-technology |
| Zdroj: | Current Topics in Medicinal Chemistry. 17:1542-1554 |
| ISSN: | 1568-0266 |
| Popis: | Dendritic nanomaterials have attracted a great deal of scientific interest due to their high capacity for multifunctionalization and potential in various biomedical applications, such as drug/gene delivery and diagnostic systems. Depending on the molecular structure and starting monomers, several different types of dendrimers have been developed, including poly(amidoamine) (PAMAM), poly(propylenimine) (PPI), and poly(L-lysine) (PLL) dendrimers, in addition to modified dendritic nanomaterials, such as Janus dendrimers and dendritic block copolymers. The chemical structure and surface modification of dendritic nanomaterials have been found to play a critical role in governing their biological behaviors. In this review, we present a comprehensive overview focusing on the synthesis and chemical structures of dendrimers and modified dendritic nanomaterials that are currently being investigated for drug delivery, gene delivery, and diagnostic applications. In addition, the impact of chemical surface modification and functionalization to the dendritic nanomaterials on their therapeutic and diagnostic applications are highlighted. |
| Databáze: | OpenAIRE |
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